El-Ellisy, D., Ewais, M., El-Awady, E., Tawfik, G. (2011). Effect of Alfacalcidol on Anemia in Renal Failure Patients. Suez Canal University Medical Journal, 14(1), 11-15. doi: 10.21608/scumj.2011.56014
Dalal El-Ellisy; Mohamed M Ewais; El-Sayed E El-Awady; Gamal A Tawfik. "Effect of Alfacalcidol on Anemia in Renal Failure Patients". Suez Canal University Medical Journal, 14, 1, 2011, 11-15. doi: 10.21608/scumj.2011.56014
El-Ellisy, D., Ewais, M., El-Awady, E., Tawfik, G. (2011). 'Effect of Alfacalcidol on Anemia in Renal Failure Patients', Suez Canal University Medical Journal, 14(1), pp. 11-15. doi: 10.21608/scumj.2011.56014
El-Ellisy, D., Ewais, M., El-Awady, E., Tawfik, G. Effect of Alfacalcidol on Anemia in Renal Failure Patients. Suez Canal University Medical Journal, 2011; 14(1): 11-15. doi: 10.21608/scumj.2011.56014
Effect of Alfacalcidol on Anemia in Renal Failure Patients
1Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Egypt.
2Department of Pharmacology & Toxicology, Faculty of Medicine, Suez Canal University, Egypt.
3Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Anemia is a major feature of chronic kidney disease (CKD). Additionally, secondary hyperparathyroidism (SHPT) has been associated with anemia in uremic patients. Administration of active vitamin D metabolites like alfacalcidol is established for PTH suppression and may also play a role in hematopoiesis. Aim:To investigate the effect of alfacalcidol on anemia and SHPT with end stage renal failure patients underwent hemodialysis. Subjects and Methods: In the present study 17 anemic patients over 15years, with serum level of PTH greater than 500pg/ml. The study was carried out by means of data collection and analysis of serum parathyroid hormone (PTH) and hemoglobin (Hb) levels in these patients. Results: Low serum PTH levels were detected in uremic patients treated with alfacalcidol. Also, in these patients, Hb levels increased. Serum PTH and Hb levels were inversely correlated. Conclusions: High-dose alfacalcidol can decrease serum PTH levels and elevate Hb level in uremic patients showing considerable resistance to Epoetin.
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