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Ewais, D., Eyada, M., Attia, F., Ahmed, A. (2016). Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients. Suez Canal University Medical Journal, 19(1), 101-106. doi: 10.21608/scumj.2016.43975
Doaa A Ewais; Moustafa M Eyada; Fadia M Attia; Amal H Ahmed. "Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients". Suez Canal University Medical Journal, 19, 1, 2016, 101-106. doi: 10.21608/scumj.2016.43975
Ewais, D., Eyada, M., Attia, F., Ahmed, A. (2016). 'Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients', Suez Canal University Medical Journal, 19(1), pp. 101-106. doi: 10.21608/scumj.2016.43975
Ewais, D., Eyada, M., Attia, F., Ahmed, A. Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients. Suez Canal University Medical Journal, 2016; 19(1): 101-106. doi: 10.21608/scumj.2016.43975

Assessment of Immunoglobulin-E and Interleukin-4 Levels in Papular Urticaria Patients

Article 11, Volume 19, Issue 1, March 2016, Page 101-106  XML PDF (522.7 K)
Document Type: Original Article
DOI: 10.21608/scumj.2016.43975
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Authors
Doaa A Ewais email 1; Moustafa M Eyada1; Fadia M Attia2; Amal H Ahmed1
1Department of Dermatology and Venereolgy, Faculty of Medicine, Suez Canal University, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Papular urticaria is a common and often annoying disorder manifested by chronic papules caused by a hypersensitivity reaction. The link between atopic immune responses (high serum IgE, IL-4) and the development of rash is clear and has been extensively evaluated in the literature. Aim: This study was designed to find possible co relation between serum levels of IgE and IL-4 and popular urticaria. Patient and Methods: A case control study was done that included 30 patients and 30 controls who were selected randomly according to the eligibility criteria. Assessment of serum IG-E and IL-4 levels was evaluated using sandwich ELISA approach. Results:  Twenty-six patients (87%) have borderline level of IgE, 1 (3%) have high level, while normal IgE level was found in 3 (10%). In the control group, 3 subjects (10%) have borderline level of IgE and 27 (90%) have normal level, while no subject had high IgE level were found. Conclusions: The present study confirmed the significantly higher values of serum IgE and IL-4 in papular urticaria patients. There was statistically significant correlation between the IL-4 and IgE levels in papularr urticaria patients.
 
Keywords
Atopy; Hypersensitivity; Urticaria; Ig-E; IL-4
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