El Merry, M., Abdellah, A., Soliman, M., Greash, M., Nada, F. (2025). The Role of Dapagliflozin in Reducing Anthracycline-Induced Cardiotoxicity in Type 2 Diabetes Mellitus Patients with Breast Cancer. Suez Canal University Medical Journal, 28(3), 1-8. doi: 10.21608/scumj.2025.418495
Mohammed Ahmed El Merry; Ahmed Tageldien Abdellah; Muhammad Soliman; Mohamed Greash; Fathy A. Nada. "The Role of Dapagliflozin in Reducing Anthracycline-Induced Cardiotoxicity in Type 2 Diabetes Mellitus Patients with Breast Cancer". Suez Canal University Medical Journal, 28, 3, 2025, 1-8. doi: 10.21608/scumj.2025.418495
El Merry, M., Abdellah, A., Soliman, M., Greash, M., Nada, F. (2025). 'The Role of Dapagliflozin in Reducing Anthracycline-Induced Cardiotoxicity in Type 2 Diabetes Mellitus Patients with Breast Cancer', Suez Canal University Medical Journal, 28(3), pp. 1-8. doi: 10.21608/scumj.2025.418495
El Merry, M., Abdellah, A., Soliman, M., Greash, M., Nada, F. The Role of Dapagliflozin in Reducing Anthracycline-Induced Cardiotoxicity in Type 2 Diabetes Mellitus Patients with Breast Cancer. Suez Canal University Medical Journal, 2025; 28(3): 1-8. doi: 10.21608/scumj.2025.418495
The Role of Dapagliflozin in Reducing Anthracycline-Induced Cardiotoxicity in Type 2 Diabetes Mellitus Patients with Breast Cancer
1Cardiology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Oncology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
3Diabetology Unit - Internal Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Although anthracyclines are a mainstay of treatment for breast cancer, they can cause serious cardiotoxicity, especially in patients who already have other medical problems including type 2 diabetic mellitus (T2DM). A sodium-glucose cotransporter-2 (SGLT2) inhibitor called dapagliflozin has demonstrated possible cardioprotective benefits. This study examines whether dapagliflozin can help T2DM patients with breast cancer postpone the development of anthracycline-induced cardiotoxicity. Methods: A total of 112 newly diagnosed breast cancer patients with T2DM were recruited and divided into two groups: the Dapagliflozin Group (n=61), which received dapagliflozin 10 mg in addition to standard antidiabetic therapy, and the Control Group (n=49), which received only standard antidiabetic therapy. Echocardiographic parameters (ejection fraction [EF], global longitudinal strain [GLS]) and biomarkers of cardiotoxicity (troponin I, BNP) were assessed at baseline and follow up at 3 and 6 months. Results: At 3 and 6 months follow up, the Dapagliflozin group showed significantly lower levels of troponin I and BNP, along with better-preserved EF and GLS compared to the control group. The cardioprotective effects of dapagliflozin became more pronounced over time. Receiver Operating Characteristic (ROC) curve analysis demonstrated that dapagliflozin had a strong predictive ability for preventing cardiotoxicity. Conclusion: Dapagliflozin showed significant cardioprotective effects in T2DM patients receiving anthracycline-based chemotherapy, suggesting its potential role in reducing anthracycline-induced cardiotoxicity. Further randomized controlled trials are necessary to confirm the cardioprotective benefits of SGLT2 inhibitors in this patient population.
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