El Merry, M., Al Hawary, A., Abdelaziz, K., Abdel Shafee, M. (2024). Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sacubi-tril/Valsartan.. Suez Canal University Medical Journal, 27(10), 1-7. doi: 10.21608/scumj.2024.416272
Mohammed A. El Merry; Ahmed A. Al Hawary; Khaled Abdelaziz; Mohamed A. Abdel Shafee. "Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sacubi-tril/Valsartan.". Suez Canal University Medical Journal, 27, 10, 2024, 1-7. doi: 10.21608/scumj.2024.416272
El Merry, M., Al Hawary, A., Abdelaziz, K., Abdel Shafee, M. (2024). 'Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sacubi-tril/Valsartan.', Suez Canal University Medical Journal, 27(10), pp. 1-7. doi: 10.21608/scumj.2024.416272
El Merry, M., Al Hawary, A., Abdelaziz, K., Abdel Shafee, M. Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sacubi-tril/Valsartan.. Suez Canal University Medical Journal, 2024; 27(10): 1-7. doi: 10.21608/scumj.2024.416272
Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sacubi-tril/Valsartan.
1Department of Cardiology, Faculty of Medicine, Suez Canal university, Ismailia, Egypt
2Department of Cardiology, Faculty of Medicine, Suez Canal university, Ismailia, Egypt.
Abstract
Background:We investigated the early improvement signs of LV systolic functions in symptomatic patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) at 3 months and 6 months after taking sacubitril/valsartan (S/V) therapy. Materials and Methods:Prospective study was done on 51 HFrEF patients receiving S/V. Baseline, 3- and 6-months evaluations were performed with routine 2D echocardiography and STE. LVEF and global longitudinal strain (GLS) were measured. Predictive value of STE was compared with routine echocardiography. Results:After three months, 71.1% of patientsrevealed LV function improvement by STE, compared to only 56.25% detected by standard 2d echo. 2d speckle tracking detected early improvement in 43.75% of patients who were not yet manifested by conventional 2d Echo. After 6 months, STE continued to identify improvement in 15.6% of patients not detected by standard echocardiography. The agreement between STE and standard echocardiography was very good (k=0.892). Moreover, 28.9% of study population didn’t show response to SV by STE, and also none of them showed response by standard echocardiography, indicating that STE has a very good negative predictive value. Conclusion: STE is effective tool in early detection of LV systolic function improvement in comparison to standard 2D echocardiography, among patients with HFrEF receiving Sacubitril/valsartan therapy.
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