Ismail, R., Kamel, A., Kherbetawy, M. (2023). Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma. Suez Canal University Medical Journal, 26(10), 26-34. doi: 10.21608/scumj.2023.353814
Radwa A. Ismail; Amr AM Kamel; Mohamed KE. Kherbetawy. "Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma". Suez Canal University Medical Journal, 26, 10, 2023, 26-34. doi: 10.21608/scumj.2023.353814
Ismail, R., Kamel, A., Kherbetawy, M. (2023). 'Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma', Suez Canal University Medical Journal, 26(10), pp. 26-34. doi: 10.21608/scumj.2023.353814
Ismail, R., Kamel, A., Kherbetawy, M. Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma. Suez Canal University Medical Journal, 2023; 26(10): 26-34. doi: 10.21608/scumj.2023.353814
Assessment of Immunohistochemical Expression of Androgen Receptor and its Correlation with Histopathological Prognostic Factors in Prostatic Carcinoma
Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Abstract
Background: Prostate carcinoma (PCa) is the second most commonly diagnosed tumor in men worldwide and is the most common male malignancy in developed countries. Androgens play a main role in the growth, differentiation, and maintenance of prostate tissue via Androgen Receptor (AR). AR expression represents a potential prognostic marker for prostatic carcinoma. Aim: this study aims to assess of immunohistochemical expression of the Androgen receptor and its correlation with histopathological prognostic factors in Prostatic carcinoma. Methods: A cross-section analytical study was conducted at the pathology department of the Faculty of Medicine at Suez Canal University. Thirty-five prostatic specimens with prostate cancer were analyzed for immunohistochemichal expression of the Androgen receptor [AR (A19611)]. Results: Out of the studied thirty-five specimens. There is a statistically significant difference between different grade groups regarding AR expression (P value =0.008) & there is a statistically significant difference between different Gleason scores regarding AR expression (P value =0.001). There is no statistically significant difference between AR expression and Age of patients, Perineural invasion, multicenticity, and no benign prostatic changes. Conclusions: This study focused on evaluating the relationship of Androgen Receptor expression with various prognostic factors associated with carcinoma prostate, AR was upregulated in prostate cancer; mainly in cancers with a worse prognosis which has a higher Gleason Score and higher-grade group.
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