Tawfik, G., Ghareeb, E., Abd El-Waheed, W., Keshawy, M., Zaki, H. (2019). Urinary Monocyte Chemoattractant Protein -1 as A Diagnostic Marker of Lupus Nephritis. Suez Canal University Medical Journal, 22(2), 122-130. doi: 10.21608/scumj.2019.94976
Gamal A Tawfik; Eman A Ghareeb; Waleed O Abd El-Waheed; Mohammed M Keshawy; Heba M Zaki. "Urinary Monocyte Chemoattractant Protein -1 as A Diagnostic Marker of Lupus Nephritis". Suez Canal University Medical Journal, 22, 2, 2019, 122-130. doi: 10.21608/scumj.2019.94976
Tawfik, G., Ghareeb, E., Abd El-Waheed, W., Keshawy, M., Zaki, H. (2019). 'Urinary Monocyte Chemoattractant Protein -1 as A Diagnostic Marker of Lupus Nephritis', Suez Canal University Medical Journal, 22(2), pp. 122-130. doi: 10.21608/scumj.2019.94976
Tawfik, G., Ghareeb, E., Abd El-Waheed, W., Keshawy, M., Zaki, H. Urinary Monocyte Chemoattractant Protein -1 as A Diagnostic Marker of Lupus Nephritis. Suez Canal University Medical Journal, 2019; 22(2): 122-130. doi: 10.21608/scumj.2019.94976
Urinary Monocyte Chemoattractant Protein -1 as A Diagnostic Marker of Lupus Nephritis
Department of Internal Medicine, Nephrology Unit, Suez Canal University, Faculty of Medicine, Egypt
Abstract
Background: Lupus nephritis accounts for significant morbidity and mortality in patients with systemic lupus erythematosus (SLE). Many biomarkers for renal involvement in SLE have been suggested in Egyptian patients; one of them is Monocyte chemoattractant protein-1 (MCP-1) which is one of the key chemokines that have chemotactic effect for monocytes and macrophages to sites of inflammation and may share in the pathogenesis of lupus nephritis (LN). Aim: The study aimed at assessing the role of MCP-1 in the early diagnosis of lupus nephritis and to explore any correlation its levels with disease activity and renal status. Subjects and Methods: The study was done as a case-control study where 60 SLE patients with lupus nephritis (30 patients with active LN and 30 patients with inactive LN) in addition to 30 healthy volunteers as control group were enrolled in the study and MCP-1 levels was determined using ELISA technique. Results:Urinary MCP-1 levels in SLE studied patients’ groups were significantly higher than their level in the control group (p = 0.0001) and it was significantly higher in active LN than in non-active LN subgroups (P-value =0.0001). Conclusion: Urinary MCP-1 can be used as a marker for LN activity. Keywords: SLE, Lupus nephritis, MCP-1
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