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Mahmoud, N., Abdalla, S., Abd El-Hamid, A. (2010). Isolated Antibody to Hepatitis B Core Antigen in Egyptian Patients with Chronic Hepatitis C Virus Infection. Suez Canal University Medical Journal, 13(1), 7-10. doi: 10.21608/scumj.2010.69767
Nora F. Mahmoud; Salah M. Abdalla; Alaa El-Din S. Abd El-Hamid. "Isolated Antibody to Hepatitis B Core Antigen in Egyptian Patients with Chronic Hepatitis C Virus Infection". Suez Canal University Medical Journal, 13, 1, 2010, 7-10. doi: 10.21608/scumj.2010.69767
Mahmoud, N., Abdalla, S., Abd El-Hamid, A. (2010). 'Isolated Antibody to Hepatitis B Core Antigen in Egyptian Patients with Chronic Hepatitis C Virus Infection', Suez Canal University Medical Journal, 13(1), pp. 7-10. doi: 10.21608/scumj.2010.69767
Mahmoud, N., Abdalla, S., Abd El-Hamid, A. Isolated Antibody to Hepatitis B Core Antigen in Egyptian Patients with Chronic Hepatitis C Virus Infection. Suez Canal University Medical Journal, 2010; 13(1): 7-10. doi: 10.21608/scumj.2010.69767

Isolated Antibody to Hepatitis B Core Antigen in Egyptian Patients with Chronic Hepatitis C Virus Infection

Article 2, Volume 13, Issue 1, March 2010, Page 7-10  XML PDF (2.06 MB)
Document Type: Original Article
DOI: 10.21608/scumj.2010.69767
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Authors
Nora F. Mahmoud1; Salah M. Abdalla1; Alaa El-Din S. Abd El-Hamid2
1Department of Microbiology and Immunology, Faculty of Pharmacy, Suez Canal University
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University
Abstract
Background: occult hepatitis B virus (HBV) infection is characterized by the presence of HBV infection with undetectable hepatitis B surface antigen (HBsAg). Such infections have been reported to be common in patients with chronic hepatitis C virus (HCV) infection.
Objective: this study investigates the prevalence of occult HBV infection in patients with chronic liver disease by HCV. 
Methods: in a cross sectional study, a toal of 3043 blood donors were screened in 2009 for the following viral markers: hepatitis C virus antibody (anti-HCV), hepatitis B surface antigen (HBsAg), and human immunodeficiency virus I/II (anti-HIV I/II). All samples negative for HBsAg and positive for anti_HCV were tested for the presence of anti-hepatitis B core antigen (anti_HBc).
Results: one hundred and fort samples (4.6%) were positive for anti-HCV. Of these 140 cases, 36 (25.71%) were anti_BHc positive. 
Conclusion: occult hepatitis B infections occur frequently in patients with chronic hepatitis C liver disease. 
Keywords
Occult hepatitis B; HBV; HCV; Coinfection, Prevalence
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