Serum Chemerin Levels relation with Waist circumference, Impaired fasting blood sugar, and Dyslipidemia in Obese Children and Adolescents

Document Type : Original Article

Authors

1 Pediatric Department, El Ibrahimiya Central Hospital, Sharqia, Egypt

2 Pediatrics Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Background: Childhood obesity is a growing global health problem associated with metabolic complications such as impaired glucose metabolism and dyslipidemia. Chemerin, an adipokine secreted by adipose tissue, has been implicated in obesity- related metabolic dysfunction. However, its relationship with clinical and biochemical parameters remains under investigation. Objectives: To evaluate the association between serum chemerin levels and waist circumference, fasting blood glucose, and lipid profile among obese children and adolescents. Methods: this cross- sectional study included 42 obese children and adolescents, ranging in age from 5 to 17, recruited from outpatient clinics in SCU hospital. There was no statistically significant difference in age, gender, or place of residence between the obese and control groups. The subjects' anthropometric and blood pressure measures were obtained. Fasting blood samples were obtained to measure serum chemerin, fasting blood, and lipid profile (serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c)). Correlation between serum chemerin levels and metabolic parameters were analyzed using Pearson’s correlation coefficient and multivariate regression models. Results: Compared to the control group, more than half (54.8%) of obese patients have waist circumferences in the 90th percentile for age and gender, which is statistically significant. The obese group had a greater mean chemerin level than the control group, but the difference was not statistically significant. By using correlation and multiple linear regression analysis, serum chemerin levels were found to be significantly correlated to impaired fasting blood sugar (r= 0.398, p = 0.009) and HDL (r= -0.386, p = 0.012). Conclusions: Elevated serum chemerin levels are significantly associated with central obesity, impaired fasting glucose, and dyslipidemia in obese children and adolescents.  These findings suggest that chemerin may serve as an early biomarker for metabolic risk assessment

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