El-Mansy, M., Hassan, M., Abou El-Nour, K., El-Hosary, W. (2017). Evaluation the Safety of Thymoquinone Loaded on Gold Nanoparticles in the Treatment of Hamster Buccal Carcinogenesis. Suez Canal University Medical Journal, 20(1), 20-28. doi: 10.21608/scumj.2017.46086
Merhan N. El-Mansy; Magda M. Hassan; Kholoud M. Abou El-Nour; Wafaa H El-Hosary. "Evaluation the Safety of Thymoquinone Loaded on Gold Nanoparticles in the Treatment of Hamster Buccal Carcinogenesis". Suez Canal University Medical Journal, 20, 1, 2017, 20-28. doi: 10.21608/scumj.2017.46086
El-Mansy, M., Hassan, M., Abou El-Nour, K., El-Hosary, W. (2017). 'Evaluation the Safety of Thymoquinone Loaded on Gold Nanoparticles in the Treatment of Hamster Buccal Carcinogenesis', Suez Canal University Medical Journal, 20(1), pp. 20-28. doi: 10.21608/scumj.2017.46086
El-Mansy, M., Hassan, M., Abou El-Nour, K., El-Hosary, W. Evaluation the Safety of Thymoquinone Loaded on Gold Nanoparticles in the Treatment of Hamster Buccal Carcinogenesis. Suez Canal University Medical Journal, 2017; 20(1): 20-28. doi: 10.21608/scumj.2017.46086
Evaluation the Safety of Thymoquinone Loaded on Gold Nanoparticles in the Treatment of Hamster Buccal Carcinogenesis
1Department of 1Oral Pathology, Faculty of Dentistry, Suez Canal University. Egypt
2Department of Oral Pathology, Faculty of Dentistry, Suez Canal University. Egypt
3Department of Chemistry, Faculty of Science, Suez Canal University. Egypt
Abstract
Background: Oral canceris one ofthe most prevalent cancers. Thymoquinone (TQ) has a potential therapeutic activity against cancer cells. Aim: This study aimed to compare the effect of TQ and TQ loaded on gold nanoparticles (GNPs) as systemic therapeutic agents through intra-peritoneal injection for 3&6 weeks after painting with DMBA (3 times/week for 14w). Material and Methods: This study was carried out on ninety male Syrian golden hamsters (n=90), its age ranged from 6 to 7 weeks, weighting 90-110 gm, purchased from Theodore Blhars Research Institute, Cairo, Egypt. Characterization of GNPs was achieved through using Ultraviolet-Visible spectroscope and transmission electron microscope (TEM). Analysis for total white blood cells (WBCs) & lymphocytes count and lymphocytes % was done. To ensure the drugs safety, liver and kidney toxicity enzymes were measured. Results: Formation of spherical and well dispersed GNPs (27nm). There was marked increase in WBCs (13.8), lymphocyte count (8.2) and liver enzymes (99.6-104.4) after DMBA painting. These markers were reduced obviously after using of GNPs-TQ for 6w to 6.1, 5.4, 56.7, and 57.5 respectively. Histopathological evaluation showed regression of carcinogenesis and regeneration of striated muscle layers when treated with GNPs-TQ. Conclusions: GNPs-TQ is considered a promising chemo-therapeutic agent in treating carcinoma, without toxic effect on liver and kidney enzymes
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