Correlation of Left Atrial Electromechanical Delay with Left Atrial Function and Level of N-Terminal Pro B-Type Natriuretic Peptide in Patients with Heart Failure with Preserved Ejection Fraction

Fareed, Ahmed Mohammed; Abdellah, Ahmed Tag Eldein; Hegazy, Hesham; Elariny, Ahmed Ibrahim

doi:10.21608/scumj.2025.399685.1701

Correlation of Left Atrial Electromechanical Delay with Left Atrial Function and Level of N-Terminal Pro B-Type Natriuretic Peptide in Patients with Heart Failure with Preserved Ejection Fraction

Document Type : Original Article

Authors

¹ Cardiovascular Medicine Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

² Cardiovascular Medicine, Faculty of Medicine, Suez Canal university, Ismailia, Egypt

10.21608/scumj.2025.399685.1701

Abstract

Background: In heart failure, atrial electromechanical delay (EMD) is frequently prolonged & may be associated with natriuretic peptide levels & left atrial function. Its function in HFpEF is still unknown & poorly understood, despite research on dilated cardiomyopathy Aim: To investigate the linkage between left atrial electromechanical delay (LA-EMD) & LA function with NT-proBNP levels in participants with HFpEF. Methods: Forty individuals exhibiting heart failure with preserved EF were recruited for this cross-sectional analysis. investigation, diagnosed in light of the most current ESC guidelines for HF. Eligible participants either had a H2FpEF score of ≥6 or a score of 3–5 accompanied by evidence of structural heart disease indicative of LV diastolic dysfunction, along with NT-proBNP levels exceeding 125 pg/mL. Results: No significant (P>0.05) correlation between (Nt-proBNp, LA-EMD, & left trial volumes & function) in all studied patients. A notable significant positive association between Nt-proBNp & each of E/A (r= 0.478), E/e’ med (r= 0.912), E/e’ lat (r= 0.876), E/e’ AV (r= 0.915), TRV (r= 0.478), & PASP (r= 0.478). A significant negative correlation (r= -0.313) between Nt-proBNP & EDT in all studied patients. Statistical analysis demonstrated a significant positive association among cLA-EMD & TRV (r= 0.387), & EPASP (r= 0.435) in all patients studied. Analysis demonstrated a strong negative association (r = –0.582, P < 0.001) among cPA-MED & BMI in all studied patients. Conclusions: The findings revealed no evidence of a statistically significant connection between Nt-proBNp & left atrial electromechanical delay including cPA-lat, cPA-med & cLA-EMD. However, NT-proBNP levels is more strongly linked to diastolic function parameters like E/A & E/e` than to LA-EMD or Left atrial volumes & functions.

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