Programmed Necrosis-mediated Cell Death and Disease: Recent Advances

Editorial

Author

Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD, USA

Abstract

Cell death classification has been based on morphological characteristics for decades. Modern advances in molecular technology enabled us to explore cell death pathways on a level of unprecedented detail. While necrosis has been considered a negative unpreventable form of cell death, recent findings demonstrate that a subtype of necrosis, namely necroptosis, is a regulated programmed process. Hence, therapeutic intervention to inhibit necroptosis-mediated loss of cells in a disease process is possible. This review highlights recent advances in programmed necrosis (necroptosis) and its potential relationship to human disease.
 
 

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