Assessment of Serum CCL20 Level in Patients with Psoriasis and Its Correlation with Disease Severity

Document Type : Original Article

Authors

1 Dermatology, Venereology, and Andrology Department, Mit Ghamr General Hospital, Dakahlia, Egypt.

2 Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

3 Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Abstract

Background: Epidermal CCL20 expression is prevalent in human psoriatic lesions. CCL20 expression is mostly limited to the psoriatic epidermis, despite the fact that dermal dendritic cells and T cells also express it in the psoriatic dermis. This suggests that epidermal keratinocytes are the primary source of CCL20 synthesis in psoriatic lesions. Additionally, psoriasis is associated with elevated serum levels of CCL20. Aim: To assess serum level of CCL20 among patients with psoriasis to help to understand the pathogenesis of psoriasis and it`s management to improve quality of life of patients with psoriasis. Materials and Methods: A case control study was conducted, and patients were recruited from the Dermatology Outpatient Clinic of the Suez Canal University Hospitals, Ismailia. Subjects were divided into two groups: patients’ group: patients with psoriasis and controls group: age and sex matched healthy controls. Serum CCL20 was measured in all subjects. Results: CCL20 levels were significantly higher in patients with psoriasis than controls (P value < 0.001). There was a significant positive correlation between CCL20 and PASI score. Conclusions: Serum CCL20 was significantly increased in psoriasis than controls. Moreover, its level was significantly correlated with disease severity. 

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