Mohamed, M., Mostafa, R., Hagras, A., Saad, H. (2025). Sperm DNA Fragmentation Index Relationship with Some Heavy Metals in Seminal Fluid of Infertile Men in Suez Canal University Hospital: A Cross-Sectional Analytical Study. Suez Canal University Medical Journal, 28(6), 51-59. doi: 10.21608/scumj.2025.441994
Mohamed Khalid Elsayed Mohamed; Rashad Mahmoud Mostafa; Abeer Mohamed Hagras; Hany Mohamed Saad. "Sperm DNA Fragmentation Index Relationship with Some Heavy Metals in Seminal Fluid of Infertile Men in Suez Canal University Hospital: A Cross-Sectional Analytical Study". Suez Canal University Medical Journal, 28, 6, 2025, 51-59. doi: 10.21608/scumj.2025.441994
Mohamed, M., Mostafa, R., Hagras, A., Saad, H. (2025). 'Sperm DNA Fragmentation Index Relationship with Some Heavy Metals in Seminal Fluid of Infertile Men in Suez Canal University Hospital: A Cross-Sectional Analytical Study', Suez Canal University Medical Journal, 28(6), pp. 51-59. doi: 10.21608/scumj.2025.441994
Mohamed, M., Mostafa, R., Hagras, A., Saad, H. Sperm DNA Fragmentation Index Relationship with Some Heavy Metals in Seminal Fluid of Infertile Men in Suez Canal University Hospital: A Cross-Sectional Analytical Study. Suez Canal University Medical Journal, 2025; 28(6): 51-59. doi: 10.21608/scumj.2025.441994
Sperm DNA Fragmentation Index Relationship with Some Heavy Metals in Seminal Fluid of Infertile Men in Suez Canal University Hospital: A Cross-Sectional Analytical Study
1Department of Dermatology and Andrology, Faculty of Medicine, Suez Canal University, Ismaila, Egypt
2Department of Forensic Medicine and Toxicology Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Introduction: Infertility affect between 8 and 12% of couples worldwide. Males are found to be solely responsible for 20-30% of infertility cases but contribute to 50% of cases overall. There are several factors affect male infertility one of them is heavy metals which considered a gonadotoxin and have bad impact on male fertility through affecting spermatogenesis and hormonal balance required for optimum sperm production. Aim of work: To demonstrate the effect of environmental exposure of some heavy metals (lead, cadmium, mercury and arsenic) on fertility and proper protection from its hazardous effect.Methods:A Cross-sectional analytical study has been conducted, that included two groups of patients. Group I: Infertile males with oligozoospermia, asthenozoospermia and or teratozoospermia group II: fertile men with proven fertility whose partners had conceived spontaneously. Semen samples had been collected after 3-5 days of abstinence and semen analysis had been performed according to the WHO laboratory manual 2021. Sperms DNA fragmentation had been assessed using aniline blue staining method. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) had been used to detect cadmium, mercury, arsenic and lead amounts in seminal plasma of all participants.Results:There is statistically significant positive correlation between levels of lead, cadmium, arsenic and mercury in seminal plasma among infertile group and level of sperm DNA fragmentation.Conclusion: heavy metals like lead, cadmium, arsenic and mercury had significant bad effect on sperm DNA fragmentation which in turn contributes in male infertility.
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