Morad, A., Eyada, M., nada, H., Maher, S., Maher, W., Marie, R. (2025). Cutaneous CCL13 mRNA and protein expression in vitiligo; a new insight to its immunopathogenesis. Suez Canal University Medical Journal, 28(7), 42-52. doi: 10.21608/scumj.2025.440838
Aya Mohamed Abd EL-Baset Morad; Moustafa Mohamed Kamel Eyada; hesham Ahmed nada; Shymaa Ahmed Maher; Wael Ahmed Maher; Radwa El- Sayed Mahmoud Marie. "Cutaneous CCL13 mRNA and protein expression in vitiligo; a new insight to its immunopathogenesis". Suez Canal University Medical Journal, 28, 7, 2025, 42-52. doi: 10.21608/scumj.2025.440838
Morad, A., Eyada, M., nada, H., Maher, S., Maher, W., Marie, R. (2025). 'Cutaneous CCL13 mRNA and protein expression in vitiligo; a new insight to its immunopathogenesis', Suez Canal University Medical Journal, 28(7), pp. 42-52. doi: 10.21608/scumj.2025.440838
Morad, A., Eyada, M., nada, H., Maher, S., Maher, W., Marie, R. Cutaneous CCL13 mRNA and protein expression in vitiligo; a new insight to its immunopathogenesis. Suez Canal University Medical Journal, 2025; 28(7): 42-52. doi: 10.21608/scumj.2025.440838
Cutaneous CCL13 mRNA and protein expression in vitiligo; a new insight to its immunopathogenesis
1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
3Clinical Sciences Department, College of Medicine, University of Sharjah, United Arab Emirates Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Vitiligo is an acquired emotionally distressing skin depigmenting immune related disorder yielded by selective melanocyte death through type 1 immune response and an emerging participation of type 2 immune response. CCL13 is a hallmark in type 2 helper T cells immune-related skin diseases. Our previous study showed that CCL13 expression, a type 2 immune response marker, was higher in vitiligo patients than controls. Aim: To investigate the relationship between mRNA and protein expressions of CCL13 in vitiligo lesions. Subjects and methods: This cross-sectional study comprised 30 non-segmental marginal recent vitiligo lesions. Immunohistochemistry, and real-time polymerase chain reaction were used to assess CCL13 protein expression, and relative CCL13 mRNA gene expression, respectively. Results: CCL13 is expressed at both genetic and tissue levels as there is relation between mRNA and protein expressions of CCL13 in vitiligo lesions. Conclusion: Relation between mRNA and protein expressions of CCL13 in vitiligo lesions may suggest its positive participation in vitiligo immune pathogenesis
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