Evaluation of the effectiveness of Catechin-Loaded Silver Nanoparticles on Chronic Toxoplasmosis in Mice: Targeting Brain Cyst Count

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1 Parasitology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

2 Pharmacognosy Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

Abstract

Background: Toxoplasmosis is a zoonotic disease caused by the protozoan Toxoplasma gondii, which is an obligate intracellular parasite. Aim: The current study was designed to evaluate the efficacy of (+)-Catechin loaded silver nanoparticles in reducing brain cyst count in chronic toxoplasmosis with the purpose of overcoming the limitations of conventional treatments. Methods: The experimental design included seven groups: Group 1 included uninfected, untreated mice. Group 2 included infected, untreated mice. Group 3 included infected mice treated with spiramycin. Groups 4 and 5 involved infected mice treated with (+)-Catechin-loaded silver nanoparticles (30 mg and 60 mg, respectively). Group 6 included infected mice treated with silver nanoparticles alone, and Group 7 involved infected mice treated solely with (+)-Catechin. Treatment effectiveness was detected by assessing Toxoplasma brain cyst count. Results: Mice treated with 30 mg and 60 mg of catechin-loaded silver nanoparticles showed the lowest mean cyst counts, establishing the highest percentage reductions of 64.63% and 58.94%, respectively with a significant statistical difference when comparing with group 2. Conclusion: In this experimental model, the study performed demonstrates that (+)-Catechin-loaded silver nanoparticles exhibit significant anti-parasitic activity against chronic toxoplasmosis

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