Soliman, N., Gobran, F., Attia, F., Elessawy, N. (2016). Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital. Suez Canal University Medical Journal, 19(1), 60-67. doi: 10.21608/scumj.2016.43948
Nashaat M Soliman; Fikry Gobran; Fadia M Attia; Nashwa R Elessawy. "Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital". Suez Canal University Medical Journal, 19, 1, 2016, 60-67. doi: 10.21608/scumj.2016.43948
Soliman, N., Gobran, F., Attia, F., Elessawy, N. (2016). 'Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital', Suez Canal University Medical Journal, 19(1), pp. 60-67. doi: 10.21608/scumj.2016.43948
Soliman, N., Gobran, F., Attia, F., Elessawy, N. Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital. Suez Canal University Medical Journal, 2016; 19(1): 60-67. doi: 10.21608/scumj.2016.43948
Autoimmune Neutropenia in Chronic Liver Disease Patients with Hepatitis C Virus at Suez Canal University Hospital
1Departments of Infectious and Endemic Diseases Faculty of Medicine, Suez Canal University, Egypt
2Departments of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Chronic hepatitis C (CHC) continues to be a public health problem in Egypt with data suggesting that its incidence may be increasing. Hepatitis C virus (HCV) infection has been associated with a variety of extra-hepatic manifestations, including autoimmune disorders. Aim: To assess the prevalence of autoimmune neutropenia (AIN) in chronic liver disease (CLD) patients with HCV. Patients and Methods: A case-control design was used to fulfill the study objective. It was conducted on 60 subjects, divided into 2 groups: group 1 (30 HCV-infected patients with low total leucocytic count [TLC] as a study group) and group 2 (30 HCV-infected patients with normal TLC as a control group). AIN was evaluated by granulocyte immuno-fluorescence test (GIFT) to detect auto-antibodies against neutrophils in HCV-infected patients presented with neutropenia. Results: The mean age of the first group was 49.9±11.6 years, while the mean age of the second group was 52.7±11.3 years. Male gender was found in 53.3% of the low TLC group compared to 63.3% in normal TLC group; Positive GIFT was found in 13.3% of study group; while none of the control group has positive GIFT. The significant variables among patients with low TLC included low ANC (OR: 5.0, 95% CI: 1.5-16.5, low HB (OR: 7.0, 95% CI: 1.4-35.5), and low PLT count (OR: 15.5, 95% CI: 3.8-63.3). Conclusion:AIN is significantly higher among CHC patients with low TLC compared to normal TLC patients.
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