Ahmed, D., Ahmed, N., Ali, D., Kamal, M., Kolieb, E. (2024). Behavioral Psychomotor Performance, Thyroid Functional and Structural Changes with Glucagon-Like Peptide-1 Receptor Agonists in Rats. Suez Canal University Medical Journal, 27(6), 46-57. doi: 10.21608/scumj.2024.438080
Dalia Ibrahim Ahmed; Nadia Abo Zied Ahmed; Dina A. Ali; Mohamed Kamal; Eman Kolieb. "Behavioral Psychomotor Performance, Thyroid Functional and Structural Changes with Glucagon-Like Peptide-1 Receptor Agonists in Rats". Suez Canal University Medical Journal, 27, 6, 2024, 46-57. doi: 10.21608/scumj.2024.438080
Ahmed, D., Ahmed, N., Ali, D., Kamal, M., Kolieb, E. (2024). 'Behavioral Psychomotor Performance, Thyroid Functional and Structural Changes with Glucagon-Like Peptide-1 Receptor Agonists in Rats', Suez Canal University Medical Journal, 27(6), pp. 46-57. doi: 10.21608/scumj.2024.438080
Ahmed, D., Ahmed, N., Ali, D., Kamal, M., Kolieb, E. Behavioral Psychomotor Performance, Thyroid Functional and Structural Changes with Glucagon-Like Peptide-1 Receptor Agonists in Rats. Suez Canal University Medical Journal, 2024; 27(6): 46-57. doi: 10.21608/scumj.2024.438080
Behavioral Psychomotor Performance, Thyroid Functional and Structural Changes with Glucagon-Like Peptide-1 Receptor Agonists in Rats
1Department of Physiology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
2Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
3Department of Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Liraglutide, a glucagon-like peptide-1(GLP-1) receptor agonist, is used to treat patients with type-2 diabetes mellitus. It may have several adverse effects on thyroid glands as GLP-1 receptors are highly expressed in thyroid glands. Aim of Study: To investigate the effect of (liraglutide) on structure and function of thyroid gland in rats and its effect on behavioral and psychomotor function. Material and Methods: This study was carried out in the animal house, Faculty of Medicine, Suez Canal University. Rats were divided randomly into 3 groups, 6 rats/group. Control group: rats received normal saline once daily, GLP -short term and GLP -long term groups: rats received (0.075 mg/kg/day) liraglutide intraperitoneally (i.p.) once daily for 11 days and 12 weeks respectively. Anxiety was assessed using open field test and forced swimming test for depressive-like behavior. Estimation of TSH, FT3, FT4 and calcitonin in addition to histopathological and immunohistochemical changes for calcitonin expression in thyroid tissue as a clinical biomarker for C-cell diseases were done. Results: Anxiety-like behaviors were significantly increased in GLP -long term group. Forced swimming showed longer immobility time in the GLP -long term group. Reduced TSH, elevated calcitonin in GLP -long term group. FT4 and FT3 were insignificantly elevated. Histopathological changes were noticed and immunohistochemical expression of calcitonin significantly increased in thyroid tissue of GLP -long term group. Conclusion: There is a probable high risk of thyroid hyperplasia and cancer in GLP -long term treatment.
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