Hematological Parameters Versus C-reactive Protein Role in The Diagnosis of Late Onset Neonatal Sepsis in Full Term Neonates at Suez Canal University Hospital

Document Type : Original Article

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1 Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Egypt

2 Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Background: Late-onset sepsis is a major cause of morbidity and death in neonates. Diagnosis may be complex. Hematological markers and C-reactive protein (CRP) are regularly measured as part of sepsis screening. However, the gold standard for diagnosing sepsis is the isolation of microorganisms in a blood culture. Aim: This study aimed to compare the role of hematological parameters versus CRP as diagnostic markers for late-onset neonatal sepsis (LONS) in full-term neonates. Patients & Methods: This case-control study included 50 neonates with LONS admitted to the Neonatal Intensive Care Unit (NICU) of Suez Canal University Hospital & 50 healthy controls both groups were rigorously investigated, including anthropometric data, clinical symptoms, key biomarkers, including CBC parameters & serum CRP. Results: Among the sepsis group, 43 patients (86%) had positive blood culture results as klebsiella (32%) & mixed organisms had the highest prevalence among positive results, staph (16%) & E.coli (8%). The Sepsis group had a significantly lower mean of Hemoglobin, platelets, & Platelet lymphocytic ratio than the control group with p-value <0.05.The Sepsis group had a significantly higher mean of C-reactive protein, C-reactive protein /Mean platelet volume and C-reactive protein /Albumin than the control group as p- value <0.001. CRP had the best sensitivity (100%), whereas CRP/MPV was more specific (100%). Conclusion: CRP has very good sensitivity for the diagnosis of LONS, while in combination with MPV gave more specificity for the diagnosis of LONS

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