Farid, M., Omran, A., Abdalla, M., Tawfik, M. (2025). Hematological Parameters Versus C-reactive Protein Role in The Diagnosis of Late Onset Neonatal Sepsis in Full Term Neonates at Suez Canal University Hospital. Suez Canal University Medical Journal, 28(7), 11-18. doi: 10.21608/scumj.2025.437680
Marina Farid; Ahmed Omran; Mohamed Osama Abdalla; Mohammad Tawfik. "Hematological Parameters Versus C-reactive Protein Role in The Diagnosis of Late Onset Neonatal Sepsis in Full Term Neonates at Suez Canal University Hospital". Suez Canal University Medical Journal, 28, 7, 2025, 11-18. doi: 10.21608/scumj.2025.437680
Farid, M., Omran, A., Abdalla, M., Tawfik, M. (2025). 'Hematological Parameters Versus C-reactive Protein Role in The Diagnosis of Late Onset Neonatal Sepsis in Full Term Neonates at Suez Canal University Hospital', Suez Canal University Medical Journal, 28(7), pp. 11-18. doi: 10.21608/scumj.2025.437680
Farid, M., Omran, A., Abdalla, M., Tawfik, M. Hematological Parameters Versus C-reactive Protein Role in The Diagnosis of Late Onset Neonatal Sepsis in Full Term Neonates at Suez Canal University Hospital. Suez Canal University Medical Journal, 2025; 28(7): 11-18. doi: 10.21608/scumj.2025.437680
Hematological Parameters Versus C-reactive Protein Role in The Diagnosis of Late Onset Neonatal Sepsis in Full Term Neonates at Suez Canal University Hospital
1Pediatrics and Neonatology Department, Faculty of Medicine, Suez Canal University, Egypt
2Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Late-onset sepsis is a major cause of morbidity and death in neonates. Diagnosis may be complex. Hematological markers and C-reactive protein (CRP) are regularly measured as part of sepsis screening. However, the gold standard for diagnosing sepsis is the isolation of microorganisms in a blood culture. Aim: This study aimed to compare the role of hematological parameters versus CRP as diagnostic markers for late-onset neonatal sepsis (LONS) in full-term neonates. Patients & Methods: This case-control study included 50 neonates with LONS admitted to the Neonatal Intensive Care Unit (NICU) of Suez Canal University Hospital & 50 healthy controls both groups were rigorously investigated, including anthropometric data, clinical symptoms, key biomarkers, including CBC parameters & serum CRP. Results: Among the sepsis group, 43 patients (86%) had positive blood culture results as klebsiella (32%) & mixed organisms had the highest prevalence among positive results, staph (16%) & E.coli (8%). The Sepsis group had a significantly lower mean of Hemoglobin, platelets, & Platelet lymphocytic ratio than the control group with p-value <0.05.The Sepsis group had a significantly higher mean of C-reactive protein, C-reactive protein /Mean platelet volume and C-reactive protein /Albumin than the control group as p- value <0.001. CRP had the best sensitivity (100%), whereas CRP/MPV was more specific (100%). Conclusion: CRP has very good sensitivity for the diagnosis of LONS, while in combination with MPV gave more specificity for the diagnosis of LONS
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