Psychiatric Disorders and Quality of Life among Patients with First Ischemic Stroke Who Received Recombinant Tissue Plasminogen Activator in Comparison with Patients Who Did Not Receive Recombinant Tissue Plasminogen Activator

Document Type : Original Article

Authors

1 Soliman Elabd Hospital, Elharam , Giza

2 Department of Psychiatric and Neurological diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

3 Department of Psychiatry, Military Medical Academy

4 Department of Psychiatry, Military Hospitals

Abstract

Background: Ischemic stroke is a major cause of death and disability and affects the quality of life of patients with several physical and psychiatric consequences. The current study aimed to assess the role of early intervention by injection of r-TPA in the window period in preventing the psychiatric burden of first ischemic stroke and improving quality of life among those patients by comparing patients who received r-TPA with those who didn't. Patients and Method: A total of 74 patients with a history of first ischemic stroke were included in the study. All patients after 6 months of the 1st Ischemic Stroke according to the WHO definition were screened by the Familial Socioeconomic Status Scale to determine the socioeconomic level and The General Health Questionnaire to detect patients with psychiatric disorders. The diagnosis of any psychiatric disorder will be based on DSM 5, using the SCID-5. Quality of life was assessed by SF-36. Results: We found no statistically significant difference between studied groups as regards QoL domain except vitality and mental health showed significant higher score in thrombolysis group. The most prevalent disorder was bipolar disorder was reported among 13.5% of group A patients and 18.9% of group B patients without statistically significant difference. Conclusion:thrombolysis therapy for the first ischemic stroke treatment is associated with better quality of life but didn't significantly affect the post-stroke incidence of psychiatric disorders or functional outcome of stroke.

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