Effect of SARS-COV-2 Infection on Liver Functions

Document Type : Original Article

Authors

1 Department of Infectious and Endemic diseases, Fever Hospital, Ismailia, Egypt.

2 Department of Endemic and Infectious diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

Abstract

Background; Liver function abnormality has been reported in cases with severe acute respiratory syndrome corona virus -2 (SARS-Cov-2) infection. Based on clinical severity, cases infected with SARS-CoV-2 can exhibit a variety of clinical manifestations, ranging from asymptomatic to severe disease. Aim of work; Assessment of the effect of SARS-Cov-2 infection on liver function test according to the severity of the disease. Subjects & methods; across sectional study was conducted, where data from 105 patients was collected, then we compared Liver function test among different severity groups (mild -moderate-severe) of SARS-CoV-19 infection. Result; Over half (53.3%) of the studied Corona virus disease -2019 (COVID -19) population had liver function test abnormalities. cases had severe COVID-19 infection had significantly higher Aspartate aminotransferase (AST) and Alanine transaminase (ALT) levels compared to mild/moderate disease severity (p=0.004 & p=0.048 correspondingly). Abnormal Liver Function Tests (LFTs) were significantly associated with comorbidities and severe COVID-19 infection. Also a significant relation was noted among abnormal LFTs and Computed Tomograghy scan (CT) of chest involvement, which was more common in 50-75% of patients. Mortality rate was significantly related with older age (p < 0.001), multiple comorbidities (p=0.002), higher LFTs (ALT, AST and Prothrombin time) (p < 0.001), & severe COVID-19 infection (p < 0.001). no significant variance was found in hospital stay duration among cases with moderate & severe COVID-19 infection (mean 7.80 ± 3.579 days vs 8.54 ± 5.249 days). Conclusion; Infection with COVID-19 and anti-COVID-19 treatments have an impact on liver function that must be evaluated in great detail

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