Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms‎ ‎as Prognostic Markers in Breast Cancer

Document Type : Original Article

Authors

1 Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

2 Department of Organic Chemistry, Faculty of Science, Suez Canal University, Egypt.

3 Department of Biochemistry, Faculty of Science, Suez Canal University, Egypt.

4 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.

Abstract

Background: the most common cancer detected in females is ‎breast ‎cancer. Several genetic alterations may have prognostic effect on ‎breast ‎cancer. Single-nucleotide polymorphisms might predict breast ‎cancer ‎management. Single nucleotide polymorphisms of PvuII ‎‎(T/C ‎substitution) and aryl hydrocarbon (G/A substitution) were ‎estimated as ‎probable genetic prognostic factors for breast cancer. Aim: ‎to assess the ‎relation between estrogen receptor alpha PvuII (rs2234693) ‎and aryl ‎hydrocarbon receptor gene polymorphisms (rs2066853) in ‎breast cancer ‎prognosis. Material and method: this study is case-control ‎that ‎enrolled 120 breast cancer patients categorized into two groups: the ‎first ‎one involved 60 females with good prognostic factors, the second ‎group ‎included 60 females with poor prognostic factors. Genotyping ‎assay ‎were done by a real-time polymerase chain reaction. Results: our ‎finding ‎revealed that the allelic frequency of wild-type genotypes for ‎PvuII and ‎AhR polymorphisms was associated with patients who had ‎better ‎prognosis for breast cancer. Their mutant genotypes were ‎significantly ‎associated with poor prognoses in breast cancer patients. ‎Conclusion: ‎PvuII, AhR genotypes were statistically significant ‎associated with ‎breast cancer ‎ prognosis. ‎

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