Aboelroos, S., Eltamany, E., Mohamed, F., Suliman, M. (2024). Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms as Prognostic Markers in Breast Cancer. Suez Canal University Medical Journal, 27(6), 24-34. doi: 10.21608/scumj.2024.421503
Sara Abd EL-Monem Aboelroos; Elsayed Hussein Mostafa Eltamany; Faten Abdelmonem Metwalli Mohamed; Marwa Awad Suliman. "Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms as Prognostic Markers in Breast Cancer". Suez Canal University Medical Journal, 27, 6, 2024, 24-34. doi: 10.21608/scumj.2024.421503
Aboelroos, S., Eltamany, E., Mohamed, F., Suliman, M. (2024). 'Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms as Prognostic Markers in Breast Cancer', Suez Canal University Medical Journal, 27(6), pp. 24-34. doi: 10.21608/scumj.2024.421503
Aboelroos, S., Eltamany, E., Mohamed, F., Suliman, M. Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms as Prognostic Markers in Breast Cancer. Suez Canal University Medical Journal, 2024; 27(6): 24-34. doi: 10.21608/scumj.2024.421503
Evaluation of PvuII (rs2234693) and AhR (rs2066853) Gene Polymorphisms as Prognostic Markers in Breast Cancer
1Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt.
2Department of Organic Chemistry, Faculty of Science, Suez Canal University, Egypt.
3Department of Biochemistry, Faculty of Science, Suez Canal University, Egypt.
4Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt.
Abstract
Background: the most common cancer detected in females is breast cancer. Several genetic alterations may have prognostic effect on breast cancer. Single-nucleotide polymorphisms might predict breast cancer management. Single nucleotide polymorphisms of PvuII (T/C substitution) and aryl hydrocarbon (G/A substitution) were estimated as probable genetic prognostic factors for breast cancer. Aim:to assess the relation between estrogen receptor alpha PvuII (rs2234693) and aryl hydrocarbon receptor gene polymorphisms (rs2066853) in breast cancer prognosis. Material and method: this study is case-control that enrolled 120 breast cancer patients categorized into two groups: the first one involved 60 females with good prognostic factors, the second group included 60 females with poor prognostic factors. Genotyping assay were done by a real-time polymerase chain reaction. Results: our finding revealed that the allelic frequency of wild-type genotypes for PvuII and AhR polymorphisms was associated with patients who had better prognosis for breast cancer. Their mutant genotypes were significantly associated with poor prognoses in breast cancer patients. Conclusion: PvuII, AhR genotypes were statistically significant associated with breast cancer prognosis.
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