Sanad, A., Karam, P., Mohamed, E., Nada, F. (2025). Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital. Suez Canal University Medical Journal, 28(3), 9-17. doi: 10.21608/scumj.2025.418783
Ahmed Mohamed Sanad; Paula S Karam; Eman H. Mohamed; Fathy A Nada. "Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital". Suez Canal University Medical Journal, 28, 3, 2025, 9-17. doi: 10.21608/scumj.2025.418783
Sanad, A., Karam, P., Mohamed, E., Nada, F. (2025). 'Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital', Suez Canal University Medical Journal, 28(3), pp. 9-17. doi: 10.21608/scumj.2025.418783
Sanad, A., Karam, P., Mohamed, E., Nada, F. Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital. Suez Canal University Medical Journal, 2025; 28(3): 9-17. doi: 10.21608/scumj.2025.418783
Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital
1Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Inflammatory and hematological factors that contribute to heart failure (HF) are of increasing interest. Our objective is to determine whether the absolute lymphocyte count (ALC) and the level of severity of HF are correlated among subjects with heart failure with reduced ejection fraction. Methods: 208 suitable individuals having heart failure with reduced ejection fraction (LVEF<50% by echocardiography) were selected for inclusion in the NYHA class—were thoroughly assessed. The neutrophil-to-lymphocyte ratio (NLR) was computed, and complete blood count with automated differential counts was carried out. Results: The Mean Lymphocyte count was 3.6 x1000, 3.4x1000, 1.8x1000, 1.5x1000 in NYHA class I, II, III and IV respectively (P value < 0.001). A significant positive correlation between BNP levels (r = 0.438, p < 0.001), and NYHA class, indicating higher values with increasing NYHA class. Neutrophil-Lymphocyte ratio (NLR) was elevated in participants with NYHA classes I and II more than participants with NYHA classes III and IV (2.9 versus 1.4, P value < 0.001). Conclusion:Low lymphocytic count and high Neutrophil-Lymphocyte ratio are linked to poor NHYA class and higher BNP levels.
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