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Tolba, S., Mossad, A., Hassan, N., Osama, M., Leheta, O. (2024). Role of Angiotensin Converting Enzyme in Development of Diabetic Nephropathy. Suez Canal University Medical Journal, 27(12), 1-6. doi: 10.21608/scumj.2024.397936
Shrouq Tolba; Ahmed Mossad; Nashwa Ramadan Hassan; Mohamed Osama; Ola F. Leheta. "Role of Angiotensin Converting Enzyme in Development of Diabetic Nephropathy". Suez Canal University Medical Journal, 27, 12, 2024, 1-6. doi: 10.21608/scumj.2024.397936
Tolba, S., Mossad, A., Hassan, N., Osama, M., Leheta, O. (2024). 'Role of Angiotensin Converting Enzyme in Development of Diabetic Nephropathy', Suez Canal University Medical Journal, 27(12), pp. 1-6. doi: 10.21608/scumj.2024.397936
Tolba, S., Mossad, A., Hassan, N., Osama, M., Leheta, O. Role of Angiotensin Converting Enzyme in Development of Diabetic Nephropathy. Suez Canal University Medical Journal, 2024; 27(12): 1-6. doi: 10.21608/scumj.2024.397936

Role of Angiotensin Converting Enzyme in Development of Diabetic Nephropathy

Article 1, Volume 27, Issue 12, December 2024, Page 1-6  XML PDF (234.88 K)
Document Type: Original Article
DOI: 10.21608/scumj.2024.397936
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Authors
Shrouq Tolba1; Ahmed Mossadorcid 2; Nashwa Ramadan Hassan email orcid 1; Mohamed Osama1; Ola F. Lehetaorcid 1
1Department of Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt.
2Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background:Diabetic Nephropathy (DN) is one of the most serious microvascular complications and its pathogenesis involves a complex interplay between metabolic and hemodynamic factors interacting through molecular and signaling pathways with growing evidence indicating that the chronic activation of renal and systemic angiotensin-converting enzyme (ACE) is considered a key factor in the pathogenesis of DN. Objectives: This study aimed to investigate the association between serum ACE levels in the development of DN in patients with type 2 diabetes mellitus (T2DM) in the Egyptian population. Methods: a case-control study enrolled 90 subjects divided into three groups: 30 diabetic patients without DN, 30 diabetic patients with DN, and 30 healthy individuals as a control group. We measured for each patient the following: serum creatinine, estimated Glomerular filtration rate (eGFR), Albumin-to creatinine ratio (ACR), as well as serum ACE level. Results: serum ACE level showed that there was a statistically significant difference between diabetic patients with the nephropathy group and the other study groups. Conclusion: Our findings indicate that serum ACE level could be a risk factor for DN among the Egyptian population.
 
Keywords
ACE level; Diabetic Nephropathy; Angiotensin
Main Subjects
Clinical Research (Medical)
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