Role of Angiotensin Converting Enzyme in Development of Diabetic Nephropathy

Document Type : Original Article

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1 Department of Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

2 Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Background:Diabetic Nephropathy (DN) is one of the most serious microvascular complications and its pathogenesis involves a complex interplay between metabolic and hemodynamic factors interacting through molecular and signaling pathways with growing evidence indicating that the chronic activation of renal and systemic angiotensin-converting enzyme (ACE) is considered a key factor in the pathogenesis of DN. Objectives: This study aimed to investigate the association between serum ACE levels in the development of DN in patients with type 2 diabetes mellitus (T2DM) in the Egyptian population. Methods: a case-control study enrolled 90 subjects divided into three groups: 30 diabetic patients without DN, 30 diabetic patients with DN, and 30 healthy individuals as a control group. We measured for each patient the following: serum creatinine, estimated Glomerular filtration rate (eGFR), Albumin-to creatinine ratio (ACR), as well as serum ACE level. Results: serum ACE level showed that there was a statistically significant difference between diabetic patients with the nephropathy group and the other study groups. Conclusion: Our findings indicate that serum ACE level could be a risk factor for DN among the Egyptian population.
 

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