Diagnostic Utility of Serum Angiopoietin-2 in Diabetic Nephropathy

Document Type : Original Article

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1 Department Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt.

2 Department of Internal Medicine, Nephrology Division, Faculty of Medicine, Suez Canal University, Egypt.

Abstract

Background: Diabetes mellitus (DM) is a major global cause of death. Diabetic nephropathy (DN) is the main microvascular complication of DM. Angiopoietin-2 (Angpt-2) enhances the progression of T2DM and accelerates vascular complications. Patients and Methods: 84 participants were recruited at Suez Canal University Hospital, Ismailia, Egypt, and divided into three equal groups: group I: patients with T2DM without albuminuria (n = 28), group II: patients with T2DM with albuminuria (n = 28), and group III: healthy volunteers (n = 28). For all participants. Laboratory work included serum creatinine, eGFR, UACR, glycemic markers, a lipid profile, and serum Angpt-2 by an ELISA-based method. Results: There was no statistically significant difference between patients with or without albuminuria regarding BMI, blood pressure, lipid profile, and glycemic control. Angpt-2 was significantly higher in patients with microalbuminuria and macroalbuminuria compared to normoalbuminuric diabetic patients and healthy controls, indeed, serum Angpt-2 progressively increases with the progression of albuminuria and renal impairment, Serum Angpt-2 showed a positive correlation with serum creatinine and a negative correlation with eGFR. Conclusions: Angpt-2 was significantly higher in albuminuric diabetic patients than the healthy controls, and it also progressively increased with the progression of UACR.  the increased level of Angpt-2 may be associated with the development of CKD, and could be used as a diagnostic marker for diabetic nephropathy and its progression
 

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