Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification

Document Type : Original Article

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Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Background: Cataract surgery induces an inflammatory response, which may cause serious adverse events if left untreated. Aim: The study compares nepafenac 0.1% eye drops (ED) versus prednisolone acetate 1% ED regarding the effect on ocular inflammation and central macular thickness (CMT). Subjects and Methods: A randomized clinical trial was conducted on patients who underwent phacoemulsification at Suez Canal University Hospital. Patients were divided into two groups: *Group (A): Used Nepafenac 0.1% *Group (B): Used prednisolone acetate 1%. All patients were scheduled for follow-up on days 1, 4, 7, and 30 after surgery, where visual acuity (VA); Intraocular pressure (IOP), and ocular inflammation were assessed. CMT was evaluated on days 7 and 30. Results: Regarding postoperative VA, IOP, and ocular inflammation no statistically significant difference was found between the two groups. Regarding ocular discomfort photophobia, and central corneal thickness (CCT) a statistically significant difference was found between the two groups at postoperative day 7; where for nepafenac and prednisolone mean ± SD of ocular discomfort was 1.20 ± 0.41 and 1.68 ± 0.75, respectively(P=0.007) and for CCT was 543.40 ± 42.13 and 580.36 ± 52.02, respectively(P=0.008). There was a statistically significant difference between the two groups regarding the change of post-operative CMT from the baseline at postoperative day 30, where the mean was 3.68 ± 33.96 and 26.0 ± 28.14 for nepafenac and prednisolone, respectively (P=0.017). Conclusion: Topical nepafenac can be an excellent alternative to topical steroids after cataract surgery.
 

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