Othman, O., EL-Nahrawy, O., Zaky, K., Moawad, E. (2024). Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification. Suez Canal University Medical Journal, 27(4), 0-0. doi: 10.21608/scumj.2024.382100
Omnia S. Othman; Osama M. EL-Nahrawy; Khaled A. Zaky; Ehab M. Moawad. "Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification". Suez Canal University Medical Journal, 27, 4, 2024, 0-0. doi: 10.21608/scumj.2024.382100
Othman, O., EL-Nahrawy, O., Zaky, K., Moawad, E. (2024). 'Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification', Suez Canal University Medical Journal, 27(4), pp. 0-0. doi: 10.21608/scumj.2024.382100
Othman, O., EL-Nahrawy, O., Zaky, K., Moawad, E. Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification. Suez Canal University Medical Journal, 2024; 27(4): 0-0. doi: 10.21608/scumj.2024.382100
Comparison of (Nepafenac 0.1%) versus (Prednisolone Acetate 1%) Ophthalmic Suspensions Regarding the Effect on Ocular Inflammation and Central Macular Thickness After Uneventful Phacoemulsification
Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background: Cataract surgery induces an inflammatory response, which may cause serious adverse events if left untreated. Aim: The study compares nepafenac 0.1% eye drops (ED) versus prednisolone acetate 1% ED regarding the effect on ocular inflammation and central macular thickness (CMT). Subjects and Methods: A randomized clinical trial was conducted on patients who underwent phacoemulsification at Suez Canal University Hospital. Patients were divided into two groups: *Group (A): Used Nepafenac 0.1% *Group (B): Used prednisolone acetate 1%. All patients were scheduled for follow-up on days 1, 4, 7, and 30 after surgery, where visual acuity (VA); Intraocular pressure (IOP), and ocular inflammation were assessed. CMT was evaluated on days 7 and 30. Results: Regarding postoperative VA, IOP, and ocular inflammation no statistically significant difference was found between the two groups. Regarding ocular discomfort photophobia, and central corneal thickness (CCT) a statistically significant difference was found between the two groups at postoperative day 7; where for nepafenac and prednisolone mean ± SD of ocular discomfort was 1.20 ± 0.41 and 1.68 ± 0.75, respectively(P=0.007) and for CCT was 543.40 ± 42.13 and 580.36 ± 52.02, respectively(P=0.008). There was a statistically significant difference between the two groups regarding the change of post-operative CMT from the baseline at postoperative day 30, where the mean was 3.68 ± 33.96 and 26.0 ± 28.14 for nepafenac and prednisolone, respectively (P=0.017). Conclusion: Topical nepafenac can be an excellent alternative to topical steroids after cataract surgery.