Age-related Neovascularization Response to Intravitreal Anti-vascular Endothelial Growth Factor

Document Type : Original Article

Authors

Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Background: A medical disorder called age-related macular degeneration (AMD) can cause impaired or absent vision in the center of the visual field. Initially, there are frequently no symptoms. A non-invasive imaging method called Spectral Domain Optical Coherence Tomography (SD-OCT) can show structural alterations in the retinal pigment epithelium (RPE) and neurosensory retina. Anti-vascular endothelial growth factor Anti-VEGF is often administered intravitreally to slow or stop the formation of blood vessels by blocking its interaction with receptors on the surface of endothelial cells. Aim: To describe changes in age-related choroidal neovascularization CNV to intravitreal anti-VEGF using OCTA. Methods: We conducted a prospective quasi-experimental study on 30 eyes of patients with neovascular AMD at the Suez Canal University Hospital's Ophthalmic Outpatient Clinic to observe how CNV responded to anti-VEGF for improved visual results and more effective follow-up in this patient group. Results: There was a highly statistically significant difference between different periods regarding both CNV area (p < 0.001), and CNV fine vessel density (p < 0.001). Conclusion: OCT-A is a quick, non-invasive, and repeatable way to examine exudative AMD. It offers precise data on the region of the CNV that responds to anti-VEGF treatment, and it is a promising imaging technique that permits assessment of the CNV fine vascular density response to anti-VEGF.
 

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Suez Canal University Medical Journal
Volume 27, Issue 1
January 2024
Pages 73-82

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