Negm, A. (2024). Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial. Suez Canal University Medical Journal, 27(1), 41-52. doi: 10.21608/scumj.2024.342791
Ahmed N. Negm. "Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial". Suez Canal University Medical Journal, 27, 1, 2024, 41-52. doi: 10.21608/scumj.2024.342791
Negm, A. (2024). 'Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial', Suez Canal University Medical Journal, 27(1), pp. 41-52. doi: 10.21608/scumj.2024.342791
Negm, A. Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial. Suez Canal University Medical Journal, 2024; 27(1): 41-52. doi: 10.21608/scumj.2024.342791
Efficacy and Safety of Dexmedetomidine Combined with Bupivacaine in Infants’ Surgeries: A Randomized Controlled Trial
Department of Anesthesia, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Dexmedetomidine has been identified as a good sedative agent in adult patients. It is usually added to local anesthetic in spinal anesthesia (SA). However, its use as an adjuvant in infant surgeries has not been well studied due to the scarcity of data. Aim: In this study, we aim to investigate the efficacy and safety of dexmedetomidine combined with bupivacaine in SA. Materials and Methods: in this randomized clinical trial, we included 46 infants who underwent infra-umbilical surgeries. We allocated patients into two groups: group 1 received bupivacaine only, and group 2 received 0.3μg/kg dexmedetomidine in addition to bupivacaine 0.5%. We assessed efficacy through evaluation of the onset and duration of sensory and motor block and time to discharge from the post-anesthesia care unit (PACU), while safety was assessed through monitoring of hemodynamics and rate of complications. Results: we found that using 0.3μg/kg dexmedetomidine in addition to bupivacaine 0.5% (group 2) was associated with a significantly prolonged duration of sensory and motor block compared to group 1. Time to discharge from PACU was earlier with group 2, but not significantly different from group 1. Although Group 1 did not witness any complications; group 2 had limited side effects that were managed appropriately. Conclusions: the combination of 0.3μg/kg dexmedetomidine with bupivacaine is safe and efficient in the anesthesia of infants undergoing minor surgeries.
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