Relation Between Levels of Fibroblast Growth Factor 23 and the Risk of Ischemic Stroke

Document Type : Original Article

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1 Department of Neurology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

2 Department Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Background: Fibroblast growth factor 23 (FGF23) is a hormone secreted by osteocytes that regulates homeostasis of phosphates by inducing phosphaturia and inhibiting the development of calcitriol. Elevated FGF23 is linked with cardiovascular events and mortality. The role of FGF23 as a risk factor for ischemic stroke is unclear. Aim: The study aimed to evaluate the levels of FGF23 and risk of ischemic stroke. Subjects and Methods: This case-control study included 44 adult ischemic stroke patients and 44 healthy controls. The levels of FGF23 were estimated using Enzyme-Linked Immune Sorbent Assay (ELISA) method. Results: FGF23 levels were significantly higher in ischemic stroke patients compared to the control group. Receiver operating characteristics (ROC) curve analysis showed high sensitivity (84.1%) and specificity (95.5%) in detecting ischemic stroke. Analysis of variance (ANOVA) test displayed a statistically significant relation between levels of FGF23 and the severity of stroke according to National Institutes of Health Stroke Scale (NIHSS). There were no significant relations between FGF23 levels and carotid artery stenosis or the lesion location on magnetic resonance imaging (MRI) according to oxford classification of stroke. Conclusion: FGF23 levels were significantly higher among ischemic stroke patients.
 

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