Maternal Serum Vitamin D Level in Preeclampsia Versus Normotensive Pregnant Females: A Comparative Study

Document Type : Original Article

Authors

1 Port Said Specialized Obstetrics and Gynecology Hospital, Port Said, Egypt

2 Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Background: Preeclampsia is a severe medical disorder affecting pregnant women. Vitamin D was thought to play an essential role in its pathogenesis. Aim: To evaluate the association between vitamin D and preeclampsia. Materials and Methods: This case-control study was conducted at the obstetrics and gynecology department at Suez Canal University Hospital. We recruited patients admitted to the ward diagnosed with mild or severe preeclampsia and another group of normotensive women as a control one. They were subjected to complete history taking, blood pressure measurement, urine analysis to detect proteinuria using a dipstick screening strip, and vitamin D analysis. Neonatal serum calcium was measured. Results: There was a significant difference in vitamin D levels which was significantly decreased in women with severe PE (p-value < 0.001). Women with severe preeclampsia were delivered by cesarean section than their peers (p-value 0.017). The neonatal total serum calcium level was significantly lower among preeclampsia groups (p=0.003). Also, the birth weight of the neonates was significantly lower among preeclampsia groups (p < 0.001). Conclusion: Vitamin D deficiency affects a significant proportion of pregnant women. Vitamin D deficiency was associated with the occurrence of PE.

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Suez Canal University Medical Journal
Volume 26, Issue 10
October 2023
Pages 18-25

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