Khalil, M., El-Hawary, A., Nasr, G., Saber, M. (2023). Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex. Suez Canal University Medical Journal, 26(7), 0-0. doi: 10.21608/scumj.2023.321285
Mohamed A. Khalil; Ahmed A. El-Hawary; Gamela M. Nasr; Mohamed Y. Saber. "Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex". Suez Canal University Medical Journal, 26, 7, 2023, 0-0. doi: 10.21608/scumj.2023.321285
Khalil, M., El-Hawary, A., Nasr, G., Saber, M. (2023). 'Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex', Suez Canal University Medical Journal, 26(7), pp. 0-0. doi: 10.21608/scumj.2023.321285
Khalil, M., El-Hawary, A., Nasr, G., Saber, M. Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex. Suez Canal University Medical Journal, 2023; 26(7): 0-0. doi: 10.21608/scumj.2023.321285
Short-Term Impact of Hyperuricemia in Acute Coronary Syndrome among Coronary Care Unit Patients in Suez Canal Authority Hospital and Ismailia Medical Complex
1Department of Cardiology, Suez Canal Authority Hospital, Ismailia, Egypt
2Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Uric acid is an independent risk factor for cardiovascular disease. Although studies were conducted abroad regarding the association of serum uric acid with in-hospital outcomes in patients with acute coronary syndrome (ACS), scarce data is yet available to show the association in our country. Aim: To determine the level of uric acid level in acute coronary syndrome patients, to assess the relation between hyperuricemia and its impact on the severity of acute coronary syndrome patients, and to assess the correlation between hyperuricemia and age in patients with ACS. Subjects and Methods: A cross-sectional comparative study was done in the Department of Cardiology, Suez Canal Authority, and Ismailia Medical Complex Hospitals. After proper ethical consideration, a total of 200 ACS patients were enrolled in the study by nonrandom sampling. Serum uric acid of all subjects was measured within 24 hours of admission, 3, 5, and 7 days after admission. Then in-hospital outcomes were observed in all subjects. Results: Died patients had a statistically significantly higher median of uric acid at admission, 3 days, 5 days, and 7 days after that survived patients. Age, DM, HTN, and death had significant direct correlations with serial uric acid measurements. Also, Killip class and CK-MB had significant direct correlations with serial uric acid measurements at admission and after 3 days of admission. Age, DM, HTN, Killip class, and hyperuricemia were significant predictors of death. Conclusion: ACS patients with hyperuricemia had a higher risk of death, even after adjustment for conventional risk factors. Measurement of uric acid levels has the potential to improve risk classification in ACS patients.
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