Comparing the Therapeutic Efficacy of Intradermal Injection of Platelet-Rich Plasma and Topical Application of Hydroquinone 2% in Melasma Treatment

Document Type : Original Article

Authors

1 Department of Dermatology, Venerology, and Andrology, Faculty of Medicine, Suez Canal University, Egypt

2 Department Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

3 Department of Dermatology, Ismailia Health Directorate, Egypt

Abstract

Background: Melasma is a condition that causes the skin to get darker over time. There have been several therapies for melasma that have had mixed effects. Objective: To compare two therapeutic modalities for melasma; topical hydroquinone 2 percent and intradermal injection of PRP. Methods: Acase-control study of 60 mixed melasma female patients with Fitzpatrick skin types II, III, and IV was conducted. The patients were then separated into two groups: group (1) was treated with intradermal PRP injections for four sessions every three weeks, while Group (2) was treated with topical hydroquinone 2 percent for nine weeks. The % decrease in baseline MASI score and digital photography were used to evaluate the results. Results: MASI score was calculated at (0, 3, 6, 9 weeks) and after the last session by one month. PRP group and the Hydroquinone group were significantly different regarding the changes in the mean score of MASI score at week 13 of the study (P = 0.002). The mean MASI score was reduced by 54.79% in the PRP group and 24.52% in the hydroquinone group at week 13. Conclusion: Melasma may benefit from the use of platelet-rich plasma as an alternative therapy.
 

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