Hassan, Y., Zeitoun, A., Abdelraheem, S., Abdelrahman, A. (2023). Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy. Suez Canal University Medical Journal, 26(6), 0-0. doi: 10.21608/scumj.2023.308898
Yomna M. Hassan; Alaa Zeitoun; Shaymaa Abdelraheem; Ahmed Abdelrahman. "Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy". Suez Canal University Medical Journal, 26, 6, 2023, 0-0. doi: 10.21608/scumj.2023.308898
Hassan, Y., Zeitoun, A., Abdelraheem, S., Abdelrahman, A. (2023). 'Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy', Suez Canal University Medical Journal, 26(6), pp. 0-0. doi: 10.21608/scumj.2023.308898
Hassan, Y., Zeitoun, A., Abdelraheem, S., Abdelrahman, A. Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy. Suez Canal University Medical Journal, 2023; 26(6): 0-0. doi: 10.21608/scumj.2023.308898
Assessment of Bone Health in Children with Nephrotic Syndrome Receiving Steroid Therapy
1Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt
2Department of Clinical and Chemical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Nephrotic syndrome is a common kidney disease in pediatrics. Aim: to assess bone health in children with nephrotic syndrome by measuring the levels of serum vitamin D, calcium, and phosphorus in those children once the diagnosis is established and after 6 weeks of starting steroid therapy. Methods: We conducted a cohort study and included children with nephrotic syndrome attending the pediatric clinic or admitted at the inpatient, Suez Canal University, Ismailia, Egypt. Blood samples were collected, and serum calcium, phosphorus, alkaline phosphatase and vitamin D were measured at time of diagnosis and 6 weeks later. Results: We included 50 patients with nephrotic syndrome; 14 of them were newly diagnosed and 36 were relapsers. In both newly diagnosed and relapsers, all parameters dropped off after steroid therapy except for ALP which did not show significant affection in newly diagnosed patients. Vitamin D level dropped 7.6 ng/ml and 6.6 ng/ml in newly diagnosed and relapsers respectively after steroid therapy. Conclusions: Although steroids are the first line therapy for nephrotic syndrome in children, their long-term use is related to negative changes in bone health. Vitamin D supplementation is recommended in those patients to keep healthy and mineralized bones.
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