Ali, W., Hasanin, E., Zamzam, M., Soliman, S. (2023). Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study. Suez Canal University Medical Journal, 26(6), 0-0. doi: 10.21608/scumj.2023.308792
Walaa S. Ali; Ehab M. Hasanin; Maha L. Zamzam; Sharehan H. Soliman. "Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study". Suez Canal University Medical Journal, 26, 6, 2023, 0-0. doi: 10.21608/scumj.2023.308792
Ali, W., Hasanin, E., Zamzam, M., Soliman, S. (2023). 'Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study', Suez Canal University Medical Journal, 26(6), pp. 0-0. doi: 10.21608/scumj.2023.308792
Ali, W., Hasanin, E., Zamzam, M., Soliman, S. Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study. Suez Canal University Medical Journal, 2023; 26(6): 0-0. doi: 10.21608/scumj.2023.308792
Induction Chemotherapy Followed by Concurrent Chemoradiation versus Concurrent Chemoradiation alone For Locally Advanced Laryngeal & Nasopharyngeal Cancers: A Retrospective Study
Clinical Oncology and Nuclear Medicine Department, Faculty of Medicine, Suez Canal University
Abstract
Background: Head and neck cancers are the sixth most common malignancy in the world, with unacceptably high mortality rates in developing countries. More than 90% of these cancers are squamous cell carcinomas (SCCs) and variants, originating from the epithelium of the mucosal lining of the upper aerodigestive tract. Aim: To evaluate the role of induction chemotherapy before concurrent chemoradiotherapy in the treatment of locally advanced non-metastatic (stage III or IV A, B) squamous cell carcinoma of laryngeal & nasopharyngeal cancers regarding progression-free survival, disease-free survival, toxicity, and organ preservation (laryngeal cancer). Patients and Methods: This is a retrospective study was conducted to estimate the value of induction chemotherapy followed by concurrent chemoradiation for locally advanced non-metastatic (stage III or IVA, B) squamous cell carcinoma of larynx & nasopharynx patients, attending Clinical Oncology Department, Suez Canal University Hospital, Ismailia, Egypt during the period from 1/2017 to 12\2018 &follow up period from 1/2019 to 12/2020. Results: This study revealed that there was no statistical significance in disease-free survival between the two groups. Regarding progression-free survival, there was a statistically significant in the Induction Chemotherapy followed by chemoradiotherapy, compared to chemoradiotherapy alone. Conclusion: Induction chemotherapy by TPF or PF is a reasonable approach for locally advanced non-metastatic nasopharyngeal and laryngeal squamous cell carcinoma as it gives better results in post-radiotherapy assessment for laryngeal cancers, and progression-free survival for both laryngeal and nasopharyngeal cancer patients.
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