Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy

Document Type : Original Article

Authors

Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Background: Mucoadhesive nasal gel provides a good platform for drug delivery to the nasal mucosa. We aimedto detect the histologic effect of Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experiment Animals. Light and transmission electron microscopy. Methods:Thirty-six mature male rabbits were placed into three groups. Non-diseased subjects receive intranasal mucoadhesive gel in the vehicle control group. The non-diseased group received intranasal Neomycin-loaded mucoadhesive gel. The non-diseased group receives intranasal ciprofloxacin-loaded mucoadhesive gel. Toluidine blue was used to stain a section of the nasal mucosa for Light and transmission electron microscopy.Results:There is a statistically insignificant difference in histological changes between the Neomycin group and Ciprofloxacin group regarding ciliated, partially deciliated cells, Goblet cells, and variable stain (P.>0.05). Conclusion: Because the antibiotic-loaded mucoadhesive gel caused little harm while preserving the nasal mucosa's integrity, it might be deemed a safe vehicle for administering topical antibiotics.
 

Keywords

Main Subjects

Files

Share

How to cite

Statistics