Mohammed, A., ElHennawi, D., El-Tabbakh, M., Kilany, O., Gardouh, A. (2023). Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy. Suez Canal University Medical Journal, 26(4), 0-0. doi: 10.21608/scumj.2023.306591
Amr S. Mohammed; Diaa Eldin M. ElHennawi; Mohamed T. El-Tabbakh; Omnia E. Kilany; Ahmed R. Gardouh. "Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy". Suez Canal University Medical Journal, 26, 4, 2023, 0-0. doi: 10.21608/scumj.2023.306591
Mohammed, A., ElHennawi, D., El-Tabbakh, M., Kilany, O., Gardouh, A. (2023). 'Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy', Suez Canal University Medical Journal, 26(4), pp. 0-0. doi: 10.21608/scumj.2023.306591
Mohammed, A., ElHennawi, D., El-Tabbakh, M., Kilany, O., Gardouh, A. Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy. Suez Canal University Medical Journal, 2023; 26(4): 0-0. doi: 10.21608/scumj.2023.306591
Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experimental Animals. Light and Transmission Electron Microscopy
Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Mucoadhesive nasal gel provides a good platform for drug delivery to the nasal mucosa. We aimedto detect the histologic effect of Mucoadhesive Gel as a Vehicle for Antibiotic Intranasal Delivery in Experiment Animals. Light and transmission electron microscopy. Methods:Thirty-six mature male rabbits were placed into three groups. Non-diseased subjects receive intranasal mucoadhesive gel in the vehicle control group. The non-diseased group received intranasal Neomycin-loaded mucoadhesive gel. The non-diseased group receives intranasal ciprofloxacin-loaded mucoadhesive gel. Toluidine blue was used to stain a section of the nasal mucosa for Light and transmission electron microscopy.Results:There is a statistically insignificant difference in histological changes between the Neomycin group and Ciprofloxacin group regarding ciliated, partially deciliated cells, Goblet cells, and variable stain (P.>0.05). Conclusion: Because the antibiotic-loaded mucoadhesive gel caused little harm while preserving the nasal mucosa's integrity, it might be deemed a safe vehicle for administering topical antibiotics.
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