Histological Evaluation of Perforated Tympanic Membrane Repair Following the Use of Autologous Platelet Rich Fibrin: An Experimental Study

Document Type : Original Article

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Department of Otorhinolaryngology, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Objective: An experimental study was conducted to determine the histological evaluation of perforated tympanic membrane repair following the use of autologous platelet-rich fibrin. Material and Methods: Forty-four dogs had significant central tympanic perforations (at least two quadrants) in their right ears and were followed for eight weeks before being randomly separated into two equal groups by lottery. PRF was utilized in the research group (A) to heal dry chronic tympanic perforation in dogs' right ears. PRF was not employed in group B; only the borders of the tympanic membrane perforation were trimmed. After 8 weeks, the closure of the perforated tympanic membrane with a platelet-rich fibrin membrane. stained with hematoxylin and eosin under a light microscope. was evaluated histopathologically for neovascularization, fibrosis, inflammation, and edema. Results: After 8 weeks, there was a statistically significant difference between the Study Group and the Control Group in terms of neovascularization, fibrosis, inflammation, and edema. Conclusion: PRF membrane can be utilized to repair tympanic membrane perforation and promote wound healing. This approach may become more popular in the future in a variety of fields since it is an autogenous material that is safe and effective, easy to use, and affordable in cost while not extending working time.
 
 

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