Naguib, H., Makledy, F., Nasr, G., Abdella, A. (2023). Use of Left Atrial Volume Index as a Marker of Diastolic Dysfunction in Chronic Kidney Disease. Suez Canal University Medical Journal, 26(3), 0-0. doi: 10.21608/scumj.2023.305214
Hesham M. Naguib; Fathy A. Makledy; Gamela M. Nasr; Ahmed T. Abdella. "Use of Left Atrial Volume Index as a Marker of Diastolic Dysfunction in Chronic Kidney Disease". Suez Canal University Medical Journal, 26, 3, 2023, 0-0. doi: 10.21608/scumj.2023.305214
Naguib, H., Makledy, F., Nasr, G., Abdella, A. (2023). 'Use of Left Atrial Volume Index as a Marker of Diastolic Dysfunction in Chronic Kidney Disease', Suez Canal University Medical Journal, 26(3), pp. 0-0. doi: 10.21608/scumj.2023.305214
Naguib, H., Makledy, F., Nasr, G., Abdella, A. Use of Left Atrial Volume Index as a Marker of Diastolic Dysfunction in Chronic Kidney Disease. Suez Canal University Medical Journal, 2023; 26(3): 0-0. doi: 10.21608/scumj.2023.305214
Use of Left Atrial Volume Index as a Marker of Diastolic Dysfunction in Chronic Kidney Disease
Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Chronic kidney disease (CKD) patients are at high risk of developing cardiovascular disease. Left atrial volume index (LAVi) is an indicator of left ventricular diastolic dysfunction. Aim: We conducted this study to find out the correlation of LAVi and other echocardiographic parameters with the estimated glomerular filtration rate (eGFR). Patients and Methods: We prospectively enrolled 170 individuals: 69 patients with CKD(40.5%) and 101 controls (59.5%). Echocardiographic parameters including systolic and diastolic volumes of the left ventricle, LAVi, ejection fraction (EF), tricuspid regurge maximum velocity (TR V MAX), and E/e ratio were measured in all participants. Results: The demographic, clinical, and echocardiographic parameters were examined. Of the 170 individuals, 69 (40.5%) patients had CKD, and 101 (59.5%) had normal renal profiles. There were 38 (55.07%) males in the CKD group and 71 (70.29%) in the control group. Patients with CKD had higher median LAVi (33.33 mL/m2 ± 11.71 vs. 22.54 mL/m2 ± 5.82; P < 0.001], higher median E/e ratio (10.41 ± 6.28 vs. 7.48 ± 2.28; P < 0.001], higher median peak TR velocity (42.47 ± 13.64 vs. 33.59 ± 12.51; P < 0.001], and lower median EF (52.79% ± 14.37 vs. 60.7% ± 8; P < 0.001]. There was a statistically significant negative correlation of eGFR with LAVi (r = -0.515, P < 0.001), TR max velocity (r = -0.44, P = 0.001), and E/e ratio (r = -0.331, P = 0.001). Conclusions: Patients with CKD have higher LAVi, Peak TR velocity, E/e ratio, and lower EF as compared to individuals without CKD. There is a significant negative correlation between eGFR and LAVi.
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