Ali, A., Abdel Wahab, A., Gad, S., Nasar, S. (2023). Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents. Suez Canal University Medical Journal, 26(3), 0-0. doi: 10.21608/scumj.2023.305005
Ahmed A. Ali; Amina M. Abdel Wahab; Suzan S. Gad; Sanaa S. Nasar. "Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents". Suez Canal University Medical Journal, 26, 3, 2023, 0-0. doi: 10.21608/scumj.2023.305005
Ali, A., Abdel Wahab, A., Gad, S., Nasar, S. (2023). 'Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents', Suez Canal University Medical Journal, 26(3), pp. 0-0. doi: 10.21608/scumj.2023.305005
Ali, A., Abdel Wahab, A., Gad, S., Nasar, S. Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents. Suez Canal University Medical Journal, 2023; 26(3): 0-0. doi: 10.21608/scumj.2023.305005
Serum Chemerin Levels Relation with Waist Circumference, Impaired Fasting Blood Sugar, and Dyslipidemia in Obese Children and Adolescents
1Department of Pediatrics, El Ibrahimiya Central Hospital, Sharqia, Egypt
2Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background:Obesity is known to be linked to adipokine dysregulation. Recent studies have discovered that the new adipokine chemerin is thought to be a modulator of obesity-related adipose tissue inflammation. Objectives: To compare Chemerin levels in matched obese and non-obese children and adolescents and to investigate the correlation between serum chemerin levels correlated with waist circumference, insulin resistance, and dyslipidemia. Methods: 42 obese children and adolescents, as well as 42 healthy volunteers, ranging in age from 5 to 17, took part in the study. The subjects' anthropometric and blood pressure measures were obtained. Fasting blood glucose, serum triglycerides (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) were all examined by the researchers (LDL-c). The quantity of circulating chemerin was measured using an ELISA kit. Results: Compared to the control group, more than half (54.8%) of obese group patients have waist circumferences in the 90th percentile for age and gender, which is statistically significant. The obese group had a greater mean chemerin level than the control group, but the difference was not statistically significant. By using correlation and multiple linear regression analysis, serum chemerin levels were found to be significantly correlated to impaired fasting blood sugar (r= 0.398, p = 0.009) and HDL (r= -0.386, p = 0.012). Conclusions: Obese children and adolescents had higher serum chemerin levels than healthy control participants, which is linked to obesity and insulin resistance.
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