Sleem, S., Marie, R., Kamel, N., Atwa, M. (2023). Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo. Suez Canal University Medical Journal, 26(2), 0-0. doi: 10.21608/scumj.2023.304782
Sahar Sleem; Radwa Marie; Noha Kamel; Mona Atwa. "Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo". Suez Canal University Medical Journal, 26, 2, 2023, 0-0. doi: 10.21608/scumj.2023.304782
Sleem, S., Marie, R., Kamel, N., Atwa, M. (2023). 'Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo', Suez Canal University Medical Journal, 26(2), pp. 0-0. doi: 10.21608/scumj.2023.304782
Sleem, S., Marie, R., Kamel, N., Atwa, M. Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo. Suez Canal University Medical Journal, 2023; 26(2): 0-0. doi: 10.21608/scumj.2023.304782
Assessment of C-X-C Motif Chemokine Ligand 10 (CXCL10) Serum Level in Patients with Vitiligo
1Department of Dermatology, Ministry of Health and Population, Faqous General Hospital, El Sharqia, Egypt
2Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Egypt.
3Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Vitiligo is a common depigmentation disorder that affects 0.1% to 2% of the population. Patients with vitiligo have an increase in autoreactive CD8+ T cells that target melanocytes in their serum and skin, resulting in melanocyte cytotoxicity.CXCL10 chemokine binds the CXCR3 receptor expressed on T cells, monocytes, and natural killer cells inducing their tissue recruitment.CXCL10 plays a role in many autoimmune diseases. Aim: Evaluate CXCL10 serum level in patients with vitiligocompared to healthy controls and detect its correlation with the disease activity.Methods:In this case-control study, 20 vitiligo patients and 20 healthy controls were enrolled. An enzyme-linked immunosorbent assay was used to compare the serum level of CXCL10 in vitiligo patients to healthy controls (ELISA).Results: The level of CXCL10serum was noticeably higher in patients with vitiligo than in controls (p=0.021) and correlated positively with disease activity (VIDA) (p < 0.001).Conclusion:CXCL10 might have a role in the pathogenesis of vitiligo and might serve as a marker for disease activity.Further large-scale studies are needed to confirm the definite role of CXCL10 in vitiligo pathogenesis.
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