Association between Urinary Cyclophilin A and Diabetic Nephropathy in Children with Type 1 Diabetes Mellitus

Document Type : Original Article

Authors

1 Neonatology Unit, MetGhamr Central Hospital, Egypt

2 Department of Pediatrics, Faculty of Medicine, Suez Canal University, Egypt

3 Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Abstract

Background: Diabetes is a group of metabolic diseases marked by hyperglycemia caused by insulin secretion, action, or both. Diabetes chronic hyperglycemia is associated with long-term damage, dysfunction, & failure of numerous organs, most notably eyes, kidneys, nerves, heart, & blood vessels. Aim and objectives: This research aimed to evaluate the association between Urinary Cyclophilin A & diabetic nephropathy in children& adolescents with Type 1 Diabetes Mellitus (T1DM). Subjects and Methods: Sixty children& adolescents were recruited consecutively from those attending diabetes outstudied case clinic in Suez Canal University Children’s Hospital. Thirty years old & gender-matched children & adolescents were recruited as the control group. Results: Concerning urinary CyPA, we found that those with microalbuminuria had the highest urinary CyPA levels when compared to others. This was statistically significant (p < 0.001). On performing post hoc analysis, we found that variation could be explained by the difference among group B included normoalbuminuric diabetic children and adolescents and group C included healthy children and adolescents (p < 0.001), among group A included microalbuminuric diabetic children and adolescents &group C (p < 0.001). Conclusion: Urinary CyPA can be used as an early indicator for Diabetic nephropathy because important great levels of urinary CyPA were detected in T1DM studied cases with DN before the presence of albuminuria.
 

Keywords

Main Subjects

Suez Canal University Medical Journal
Volume 26, Issue 2
February 2023
Pages 25-34

Files

Share

How to cite

Statistics