Mohamed, M., Zeitoun, A., Attia, F., AbdAllah, N. (2023). Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia. Suez Canal University Medical Journal, 26(2), 17-24. doi: 10.21608/scumj.2023.299510
Marwa A. Mohamed; Alaa El-Din A. Zeitoun; Fadia M. Attia; Nouran B. AbdAllah. "Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia". Suez Canal University Medical Journal, 26, 2, 2023, 17-24. doi: 10.21608/scumj.2023.299510
Mohamed, M., Zeitoun, A., Attia, F., AbdAllah, N. (2023). 'Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia', Suez Canal University Medical Journal, 26(2), pp. 17-24. doi: 10.21608/scumj.2023.299510
Mohamed, M., Zeitoun, A., Attia, F., AbdAllah, N. Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia. Suez Canal University Medical Journal, 2023; 26(2): 17-24. doi: 10.21608/scumj.2023.299510
Correlation between Degree of Asthma Severity and Malondialdehyde in Asthmatic Children in Ismailia
1Pediatric Department, Faculty of Medicine, Suez Canal University, Egypt
2Clinical Pathology Department, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Oxidative damage of several biomolecules is strongly involved in the pathogenesis of asthmatic inflammation. It is affecting airway functions causing an increase in the frequency of asthma attacks and deterioration. Aim: To determine Malondialdehyde level in both asthmatic children and the control group and to correlate its level to the degree of asthma severity.Subjects and Methods: Malondialdehyde (MDA) was measured in a group of Egyptian asthmatic children (55) and their matching controls (55) with an age range from 5 to 15 years who were attending the outpatient clinic in Suez Canal university hospital. Results: MDA level mean was higher in the studied asthmatic children than the control group being 3.32 ± 2.09 nmol/ml and 1.27 ± 0.20 nmol/ml respectively with a statistically significant difference. MDA level mean was found to correlate significantly and proportionally to the degree of asthma severity being 2.05 ±1.21 nmol/ml in intermittent asthma, 2.75 ± 1.75 nmol/ml in mild persistent, and 4.66 ± 2.12 nmol/ml in moderate persistent (p value<0.001). Conclusion:The findings of our study further strengthen the evidence that the altered oxidant-antioxidant balance is associated with airway obstruction.
View on SCiNiTO
Top