Serum Level of Survivin in Patients with Alopecia Areata and its Association with Disease Severity and Progression

Document Type : Original Article

Authors

1 Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.

2 Department of Dermatology and Venereology, Ministry of Health and Population, El-Tour General Hospital, South Saini, Egypt.

3 Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

Abstract

Background: Alopecia areata (AA) is an acquired cytotoxic T-cell immune-mediated hair loss disorder. The autoimmune attack triggers apoptosis with rapid progression of hair follicles (HFs) from the anagen to catagen and telogen phases of the hair cycle. Survivin is an inhibitor of apoptosis protein responsible for cell cycle regulation and apoptosis inhibition. Its expression has been determined in proliferating anagen HF cells, whereas its expression prominently decreases during the catagen phase. Aim: This study aimed to evaluate serum survivin level in AA patients and its relationship with AA severity and progression. Subjects and Methods: The study included 38 AA patients and 38 healthy controls. Alopecia areata severity was assessed by the severity of the Alopecia Tool score. Serum survivin level was measured by enzyme-linked immune-sorbent assay. Results: Serum Survivin level was significantly lower in AA patients than in controls (p < /em>= 0.009). Moreover, the level was significantly lower in patients with progressive disease than in those with stable disease (p < /em><0.001). A significant negative correlation was found between survivin serum level and AA severity (p < /em> < 0.001) and duration (p=0.003). Conclusion: Survivin serum level was decreased in AA patients. Thus, survivin could have a potential role in AA immune pathogenesis and its serum level might be a predictor for AA severity and progression.
 

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