Harfosh, A., Abo-Ghalia, A., Hegab, A., El-Bakhshwangi, M., Abdel-Halim, H. (2023). Effects of the Nano-Profenofos Pesticide on the Chromosomes of Albino Rats. Suez Canal University Medical Journal, 26(1), 11-16. doi: 10.21608/scumj.2023.283959
Asma S. Harfosh; Ahmed H. Abo-Ghalia; Ahmed M. Hegab; Mohamed I. El-Bakhshwangi; Howyda I. Abdel-Halim. "Effects of the Nano-Profenofos Pesticide on the Chromosomes of Albino Rats". Suez Canal University Medical Journal, 26, 1, 2023, 11-16. doi: 10.21608/scumj.2023.283959
Harfosh, A., Abo-Ghalia, A., Hegab, A., El-Bakhshwangi, M., Abdel-Halim, H. (2023). 'Effects of the Nano-Profenofos Pesticide on the Chromosomes of Albino Rats', Suez Canal University Medical Journal, 26(1), pp. 11-16. doi: 10.21608/scumj.2023.283959
Harfosh, A., Abo-Ghalia, A., Hegab, A., El-Bakhshwangi, M., Abdel-Halim, H. Effects of the Nano-Profenofos Pesticide on the Chromosomes of Albino Rats. Suez Canal University Medical Journal, 2023; 26(1): 11-16. doi: 10.21608/scumj.2023.283959
Effects of the Nano-Profenofos Pesticide on the Chromosomes of Albino Rats
1Plant Protection Research Institute, Agriculture Research Center, Dokki, Giza, Egypt.
2Suez Canal University, Faculty of Science, Zoology department, Ismailia, Egypt
Abstract
Background:The management of insect pests through the formulations of nanomaterials-based insecticides is not uncommon recently. Traditional strategies used in agriculture are insufficient, and the application of chemical pesticides has adverse effects on animals and human beings apart from the decline in soil fertility. Therefore, nanotechnology would provide green and efficient alternatives for the management of insect pests in agriculture without harming nature. However, the disadvantages of nanotechnology are possible in both occupational and residential environments. Aim: This study aimed at the evaluation of the genotoxic effect of the pesticide Profenofos (organophosphorus) and its nanoparticles in rats. This was assessed by the study of chromosomal aberrations. Materials and Methods: Healthy male rats were orally fed with different doses (1/20 and 1/40 of the LD50) of Profenofos and nano-Profenofos in multi doses for three successive days at two different time intervals (24 hours and one week) post-treatment. Results: The data revealed a significant increase in the number of chromosomal abnormalities in both pesticide-treated animals compared to their controls. The maximum genotoxic effect was induced by the nano-Profenofos pesticide. Conclusion: The results obtained in this study suggest that nano-pesticides may have higher genotoxic and biological effects than their regular pesticides.
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