Tawfek, A., Elgharieb, M., Alnahass, H., Alnahrawy, O., Gab-Alla, A. (2022). Effect of Intravitreal Injection of Ranibizumab on Macular Perfusion by Optical Coherence Topography Angiography. Suez Canal University Medical Journal, 25(2), 1-6. doi: 10.21608/scumj.2022.223250
Ahmed Z. Tawfek; Mervat E. Elgharieb; Hussein S. Alnahass; Osama M. Alnahrawy; Amr A. Gab-Alla. "Effect of Intravitreal Injection of Ranibizumab on Macular Perfusion by Optical Coherence Topography Angiography". Suez Canal University Medical Journal, 25, 2, 2022, 1-6. doi: 10.21608/scumj.2022.223250
Tawfek, A., Elgharieb, M., Alnahass, H., Alnahrawy, O., Gab-Alla, A. (2022). 'Effect of Intravitreal Injection of Ranibizumab on Macular Perfusion by Optical Coherence Topography Angiography', Suez Canal University Medical Journal, 25(2), pp. 1-6. doi: 10.21608/scumj.2022.223250
Tawfek, A., Elgharieb, M., Alnahass, H., Alnahrawy, O., Gab-Alla, A. Effect of Intravitreal Injection of Ranibizumab on Macular Perfusion by Optical Coherence Topography Angiography. Suez Canal University Medical Journal, 2022; 25(2): 1-6. doi: 10.21608/scumj.2022.223250
Effect of Intravitreal Injection of Ranibizumab on Macular Perfusion by Optical Coherence Topography Angiography
Department of Ophthalmology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt
Abstract
Background:Diabetic retinopathy (DR), diabetic microangiopathy, is characterized by capillary nonperfusion, which increases the expression of vascular endothelial growth factor (VEGF). Intravitreal ranibizumab injection was approved for the treatment of diabetic macular edema. Objective:Assessment of the efficacy of intravitreal injection of ranibizumab on macular perfusion. Patients and Methods: Quasi-experimental interventional study was undertaken at Suez Canal University hospitals, Ophthalmology Department on patients who were diagnosed as having diabetic macular edema by optical coherence topography. A total of 60 participants were evaluated by taking a complete ophthalmologic history, examination, and investigations by the use of a pre-designed checklist,and intravitreal injection of anti-VEGF was done. Results: Our study showed that the study group has consisted of 71.4% females and 28.3% males. The mean ± SD of the average superficial foveal avascular zone (sFAZ) area was 263.33 ± 61.80 µm2 pre-injection, 208.33 ± 40.41 post-injection with an improvement of 55.0 ± 21.39 (20.22%). The mean ± SD of the average deep foveal avascular zone (dFAZ) area was 1287.83 ± 220.22 µm2 pre-injection, 624.0 ± 65.35 post-injection with an improvement of 663.83 ± 281.0 (49.54%). Conclusion: Intravitreal injection of anti-VEGF was very effective in diabetic macular edema. Analysis of vascular density changes following anti-VEGF treatment for DME using Optical coherence tomography angiography (OCTA) was remarkably effective.
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