Multiple Sclerosis and Vitamin D: Is there a Link in the Multifactorial Model?

Editorial

Author

Department of Clinical & Chemical Pathology, Faculty of Medicine, Suez Canal University, Ismailia Egypt; Research fellow, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.

Abstract

MS is a rare neurodegenerative disease with an immunopathological background. Although, it has a rather low global prevalence, it can be considered among one of the most common youth disabling disorders that are not related to trauma. It is also classified as a complex disease with many susceptibility genes incriminated in its etiology and prognosis. In addition, several well identified and extensively studied environmental factors are implicated as vitamin D metabolism & ultraviolet B (UVB) exposure, Epstein Barr virus (EBV) infection, smoking and morbid obesity. The infamous relationship between Vitamin D and MS has been an area of extensive research in many aspects; pathophysiology, disease course, prognosis and even response to treatment.
 

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