Attea, H., Abd El Hamid, A., Keshawy, M., Khedr, M. (2021). Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D?. Suez Canal University Medical Journal, 24(2), 128-134. doi: 10.21608/scumj.2021.192460
Heba A Attea; Alaa El Din S Abd El Hamid; Mohammed M Keshawy; Mohamed S Khedr. "Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D?". Suez Canal University Medical Journal, 24, 2, 2021, 128-134. doi: 10.21608/scumj.2021.192460
Attea, H., Abd El Hamid, A., Keshawy, M., Khedr, M. (2021). 'Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D?', Suez Canal University Medical Journal, 24(2), pp. 128-134. doi: 10.21608/scumj.2021.192460
Attea, H., Abd El Hamid, A., Keshawy, M., Khedr, M. Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D?. Suez Canal University Medical Journal, 2021; 24(2): 128-134. doi: 10.21608/scumj.2021.192460
Insulin Resistance in Chronic Kidney Disease: Is There a Distinct Role of Vitamin D?
1Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background: Chronic kidney disease (CKD) is associated with significant morbidity and mortality. Many factors including inflammation, oxidative stress, and vitamin D deficiency contribute to insulin resistance (IR). Vitamin D requires attention because of the kidney’s involvement in vitamin D metabolism, the high prevalence of vitamin D deficiency in CKD, and the effect of vitamin D that may cover multiple factors contributing to IR in CKD, as inflammation. Aim: To Identify the role of vitamin D deficiency in diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients. Patients and Methods: The study was performed as a cross-sectional study including 84 patients with T2DM admitted in Suez Canal University Hospitals. Results: In diabetics with normal kidney function 64.3% of patients had sufficient level of vitamin D, while 14.3% of patients had vitamin D deficiency. In diabetics with late nephropathy 46.4% of patients had vitamin D deficiency with significant relationship between the progress of DN and vitamin D level (p value ≤ 0.05). Conclusion:vitamin D deficiency is strongly associated with DN.
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