Attea, H., Abd El Hamid, A., Keshawy, M., Khedr, M. (2021). Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt. Suez Canal University Medical Journal, 24(2), 104-108. doi: 10.21608/scumj.2021.192013
Heba A Attea; Alaa El Din S Abd El Hamid; Mohammed M Keshawy; Mohamed S Khedr. "Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt". Suez Canal University Medical Journal, 24, 2, 2021, 104-108. doi: 10.21608/scumj.2021.192013
Attea, H., Abd El Hamid, A., Keshawy, M., Khedr, M. (2021). 'Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt', Suez Canal University Medical Journal, 24(2), pp. 104-108. doi: 10.21608/scumj.2021.192013
Attea, H., Abd El Hamid, A., Keshawy, M., Khedr, M. Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt. Suez Canal University Medical Journal, 2021; 24(2): 104-108. doi: 10.21608/scumj.2021.192013
Insulin Resistance in Diabetic CKD: A Hospital-Based Study in Egypt
1Department of Internal Medicine, Faculty of Medicine, Suez Canal University, Egypt
2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt
Abstract
Background:The presence of insulin resistance (IR) and compensatory hyper-insulinemia is strongly associated with chronic kidney disease (CKD) stages and constellates with other abnormalities such as obesity, hypertension, and dyslipidemia. CKD is associated with significant morbidity and mortality. A variety of factors, including inflammation, oxidative stress and metabolic acidosis are associated with insulin resistance. Aim: To identify the relationship between insulin resistance and diabetic kidney disease (DKD). Patients and Methods: The study was performed as a cross-sectional study including 84 patients with type 2 diabetes mellitus admitted in Suez Canal University Hospitals. Results: In diabetics with normal kidney function 28.6% of had IR, while 78.6% of diabetic patients with late DKD had IR according to HOMA- IR with significant relationship between the progress of DKD and IR(p value ≤ 0.05).Conclusion: The presence of insulin resistance is strongly associated with DKD and its progress.
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