Specific Language Impairment (SLI) is a communication neurodevelopmental disorder that manifests at the age of 3-5 years when a child lags his chronological speech development age by one year in the absence of medical, environmental, and psychological risk factors. SLI has been known to be highly heritable. Many studies have demonstrated different genes and loci to be implicated in SLI through linkage studies, the commonest of which were, FOXP2, ATP2C2, CMIP, CNTNAP2, DCDC2, KIAA0319, DYX1C1, SRPX2, NFXL1, ERC1, SETBP1, SEMA6D, AUTS2, and GRIN2A and B. In this review, we aim to present a comprehensive summary of the genes reported to be responsible or correlated to SLI and the common non-synonymous variants for each gene and their potential pathophysiological impact on normal speech development.
Eldesouki, R. (2021). Specific Language Impairment Genes, Variants and Possible Gene-based Interventions. Suez Canal University Medical Journal, 24(1), 1-11. doi: 10.21608/scumj.2021.155491
MLA
Raghda E Eldesouki. "Specific Language Impairment Genes, Variants and Possible Gene-based Interventions", Suez Canal University Medical Journal, 24, 1, 2021, 1-11. doi: 10.21608/scumj.2021.155491
HARVARD
Eldesouki, R. (2021). 'Specific Language Impairment Genes, Variants and Possible Gene-based Interventions', Suez Canal University Medical Journal, 24(1), pp. 1-11. doi: 10.21608/scumj.2021.155491
VANCOUVER
Eldesouki, R. Specific Language Impairment Genes, Variants and Possible Gene-based Interventions. Suez Canal University Medical Journal, 2021; 24(1): 1-11. doi: 10.21608/scumj.2021.155491
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