Suez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Surgical Treatment of Unstable Posterior Wall Acetabular Fractures1281354356110.21608/scumj.2017.43561ENSamir AElshouraDepartment of Orthopedics, Faculty of Medicine, Al Azhar University, Damietta, EgyptOsman AMohamedDepartment of Orthopedics, Faculty of Medicine, Al Azhar University, Damietta, EgyptFathy HSalamaDepartment of Orthopedics, Faculty of Medicine, Al Azhar University, Damietta, EgyptMohamed AHassanDepartment of Orthopedics, Faculty of Medicine, Al Azhar University, Damietta, EgyptJournal Article20190802<strong><em><span>Background</span></em><span>: Acetabular fractures are severe injuries, generally caused by high-energy trauma, most frequently from traffic accidents or falls from heights. Fractures of the extremities, head, chest, abdomen and pelvic ring injuries are most commonly associated injuries. <em>Aim:</em> To evaluate the results of surgical treatment of unstable posterior wall fractures with open reduction and internal fixation. <em>Patients and Methods:</em> In this study, 16 patients with unstable posterior wall acetabular fractures. As regard age of the patients, it ranged from 20- 60 years with mean 32.8±9.12 years. They were 12 males and 4 females. The cause of trauma was road traffic accident (RTA) in all patients. All patients were operated upon with open reduction and internal fixation using reconstruction plates and cancellous screws for treatment posterior acetabular fracture in the period from March 2014 to March 2016 with follow up period ranging from 2 months to 2 years. <em>Results:</em> Satisfactory functional outcome was obtained in 12 cases, excellent in 5 and good in 7 cases, while unsatisfactory functional outcome was obtained in 4 cases, fair in 3 and poor in one. <em>Conclusions:</em> Open reduction and internal fixation is an effective method for treatment of unstable posterior acetabular wall fractures. Surgical treatment leads to early rehabilitation and avoiding complications as osteoarthritis </span></strong>https://scumj.journals.ekb.eg/article_43561_95c0f9d54ec4f8faef3af3a3945a3d80.pdfSuez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Evaluation of Vitamin D Levels in Women with Carpal Tunnel Syndrome1361414356210.21608/scumj.2017.43562ENShaimaa MOkashaDepartment of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, EgyptMaii AAbdel-latifDepartment of Physical Medicine, Rheumatology and Rehabilitation, Faculty of Medicine, Suez Canal University, EgyptMarwa OrabiDepartment of Neurology, Faculty of Medicine, Suez Canal University, EgyptJournal Article20190802<strong><em>Background</em></strong><strong><em>:</em></strong><strong>For decades, the role of vitamin D was limited to the formation and maintenance of bone as well as homeostasis of calcium and phosphate. Vitamin D is a steroid molecule, mainly synthesized in the skin from 7 dehydro cholesterol by ultraviolet irradiation or obtained through the diet. The major circulating metabolite of vitamin D is 25(OH) Vitamin D (25(OH)D), with a half-life of 21–30 days. Serum concentration of 25(OH) D is the most reliable biochemical index of vitamin status. Aim</strong><strong>: </strong><strong>The goal of the present study was to investigate the relationship between vitamin D levels and carpal tunnel syndrome (CTS)</strong><strong><em>Patients and Methods:</em></strong><strong>This study included 50 female patients with mild to moderate CTS and assessed their serum 25-hydroxyvitamin D levels. We included patients with a diagnosis of CTS based on both the clinical symptoms and positive neurophysiology. Controls (electrophysiological negative symptomatic patients) were evaluated 50 patients matched with sex and age clinically by rheumatologist. <em>Results:</em> the mean age of patients with CTS symptoms and control group were 49.2 ± 10.6 (range 21–54) and 49.7 ± 10.6 (range 20–55), respectively, with no significant difference between the two groups (p = 0.534). Patients with CTS symptoms had significantly lower 25(OH) D levels compared to controls. There’s significance difference among the CTS patient regarding Boston Carpal Tunnel Questionnaire (BQ).</strong><strong> <em>Conclusion:</em> a potential link between vitamin D status and the occurrence of CTS is suggested.</strong>https://scumj.journals.ekb.eg/article_43562_57bbecb03a7b626b8f1545b3996c38cf.pdfSuez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Association of Leptin Gene G2548A Polymorphism and Leptin Resistance with Insulin Resistance and Obesity among Egyptians1421524356310.21608/scumj.2017.43563ENSara AAboelrosDepartment of Clinical Pathology, Faculty of Medicine, Suez Canal University, EgyptAbdel Malik MNassarDepartment of Clinical Pathology, Faculty of Medicine, Suez Canal University, EgyptMohamed MEl ShabrawyDepartment of Clinical Pathology, Faculty of Medicine, Suez Canal University, EgyptRanya MHassanDepartment of Clinical Pathology, Faculty of Medicine, Suez Canal University, EgyptAhmed TAbdelellahDepartment of Cardiology, Faculty of Medicine, Suez Canal University, EgyptJournal Article20190802<strong><em>Background</em></strong><strong> leptin (<em>LEP</em>) and leptin receptor (<em>LEPR</em>) genes have been correlated to the pathophysiology of obesity, diabetes, metabolic syndrome and associated complications. LEP G2548A (rs7799039) is a single nucleotide polymorphism (SNP) in leptin gene, the association between G2548A and increased leptinemia is controversial.</strong><strong><em>Aim</em></strong><strong> to study the correlation between </strong><strong>LEP G2548A and leptin resistance and their accompaniment with insulin resistance among obese Egyptians. </strong><strong><em>Patients & Methods:</em></strong><strong>Forty-four obese patients and 44 normal controls were included, and polymerase chain reaction restriction fragment length polymorphism method were used. Serum lipid profile, blood glucose, serum leptin and insulin were also measured</strong><strong>. </strong><strong><em>Results</em></strong><strong> Statistically significant positive correlations between insulin resistance and age, diabetes mellitus, hypertension, family history of cardiac disease, hyperlipidemia, family history of obesity, BMI, serum cholesterol, serum triglycerides, serum LDL cholesterol and allele G (for all p-value =0.0001 except cardiac disease p-value =0.006 and allele G p-value=0.001) were found. The percentages of </strong><strong>heterozygous </strong><strong>AG and </strong><strong>homozygous </strong><strong>AA genotypes were statistically significantly higher among obese group than among non-obese group (52.3% and 25% <em>vs.</em> 18.2 and 2.3%, respectively) (p=0.001). In contrast, non-obese group showed statistically significant higher percentage of homozygous genotype GG (Wild type) in comparison to obese group (79.5% <em>vs.</em> 25%, respectively) which is statistically significant (p=0.001). </strong><strong><em>Conclusion</em></strong><strong>Current results concluded that leptin gene</strong><strong> G2548A</strong><strong> polymorphism could be a genetic marker of obesity in Egypt. Th</strong><strong>e correlation between </strong><strong>(SNP) in the leptin gene (G2548A) and insulin resistance among obese Egyptians</strong><strong> would help in improving knowledge and management of obesity </strong><strong>among Egyptian patients</strong><strong>.</strong>https://scumj.journals.ekb.eg/article_43563_4bafe4ea0e9b5e635c4edb3ad45cc653.pdfSuez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Liver Involvement in Systemic Lupus Erythematosus Patients1611674358910.21608/scumj.2017.43589ENAmira AShahinDepartment of Rheumatology & Rehabilitation, Faculty of Medicine, Cairo university, EgyptGhada SAlazkalanyDepartment of Rheumatology & Rehabilitation, Faculty of Medicine, Cairo university, EgyptMaha SHasaballahDepartment of Rheumatology & Rehabilitation, Faculty of Medicine, Cairo university, EgyptAl Shaymaa AEwielaJournal Article20190803<strong><em>Background:</em></strong><strong> Systemic lupus erythematosus (SLE) is a potentially severe, frequently disabling autoimmune disease with multi-organ involvement</strong><strong>. Liver involvement in SLE is not uncommon. It is frequently asymptomatic and limited to liver tests abnormalities. <em>Aim</em></strong><strong><em>:</em></strong><strong> To detect the frequency and nature of liver involvement in SLE patients and to correlate these with other organ involvement</strong><strong>. <em>Patients and</em> </strong><strong><em>Methods:</em></strong><strong>A retrospective study included</strong><strong> 200 SLE patients who had admitted at Rheumatology and Rehabilitation department, Faculty of Medicine, Cairo university. </strong><strong>P</strong><strong>atients</strong><strong>were classified</strong><strong> into two groups Group I (no liver affection) and Group II (with liver affection)</strong><strong>.</strong><strong> These group</strong><strong>s</strong><strong> were</strong><strong>sub</strong><strong>divided into </strong><strong>sub</strong><strong>groups</strong><strong>;</strong><strong> A (6 patients with AIH), B</strong><strong>(194 patients without AIH), C</strong><strong>(13 patients with fatty changes), D ( 187 patients without fatty changes), E ( 6 patients with HCV) & F (194 patients without HCV).</strong><strong>Patients were subjected to full history taking, clinical examination and laboratory investigations; the erythrocyte sedimentation rate (ESR), complete blood count (CBC), serum creatinine, alanine transaminases (ALT), aspartate transaminases (AST), Autoantibodies (ANA and Anti DNA,</strong><strong>and </strong><strong>Anti</strong><strong>LKM), serum complement levels (C3, C4), urine analysis, total albumin in 24 hours urine and HCV by PCR. Liver and renal biopsies were done in selected patients. Patients were also subjected to plain X-ray and abdominal sonography. Assessment of disease damage was measured by using systemic lupus erythematosus international collaborating clinic (SLICC). </strong><strong><em>Results:</em></strong><strong>L</strong><strong>iver involvement was found in 23 SLE patients (11%). We classified the 23 patients into 5 major groups: Autoimmune hepatitis in 6 patients (26%), Cholangitis in 1 patient (4.3%), portal venous thrombosis in 2 patients (8.6%), Cirrhosis in 1 patient (4.3%), Liver congestion in 1 patient (4.3%), fatty changes in 13 patients (56.6%), HCV in 6 patients (26%). A significant relation between the age of onset</strong><strong>, </strong><strong>presence of ascites</strong><strong>and </strong><strong>SLICC in group A </strong><strong>compared to</strong><strong> B (p=0.034</strong><strong>, </strong><strong>p=0.007</strong><strong>and </strong><strong>p=0.010</strong><strong>respectively</strong><strong>)</strong><strong>was found. </strong><strong><em>Conclusion:</em></strong><strong> Liver</strong><strong>in SLE is the least organ affected. The </strong><strong>younger the age group of lupus patients with AIH, the more the organ damage</strong><strong>. </strong>https://scumj.journals.ekb.eg/article_43589_7ca5e2a089dc360b00d5de65984d8671.pdfSuez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Types and Impacts of Headache on Work and Life among Physicians1681764359010.21608/scumj.2017.43590ENShaimaa AmerDepartment of Community Medicine (Occupational Health Group), Faculty of Medicine, Suez Canal University, EgyptMohamed ElsamahyDepartment of Neuropsychiatry, Faculty of Medicine, Suez Canal University, EgyptJournal Article20190803<strong><em>Background:</em></strong><strong> Headache is the one of the most frequent diagnoses in neurology outpatient clinics. More than 90% of individuals experience headache from time to time in their life.</strong><strong> Most headaches occur in the daytime and </strong><strong>affect nearly all aspects of life. Family, friendships, daily living activities, exercise, diet, sleep and </strong><strong>work productivity</strong><strong> are all affected</strong><strong>. </strong><strong><em>Aim:</em></strong><strong> To determine types of headache and evaluate the degree of affected daily achievement of physicians suffering from headache.</strong><strong><em>Patients and Methods:</em></strong><strong> full patient history record and neurological examination were applied. The MIDAS (Migraine Disability Assessment) Questionnaire was used to assess disability in daily achievement at work and home caused by </strong><strong>headache over the last three months. </strong><strong>MIDAS</strong><strong> was applied on 207 female and male resident physicians suffering from headache. All subjects are working at Suez Canal University and Ismailia general hospitals with different specialties</strong><strong>. </strong><strong><em>Results:</em></strong><strong>The results showed that 80.19%, 19.32% and 0.48% of the subjects are suffering from tension-type headache, migraine and cluster headache respectively. Of all the subjects, 40.5% reported little or no disability, 14.01 % had Mild disability, 23.6% showed moderate disability, 21.7% reported severe disability. There was strong positive correlation between disability grade, number of days with headache and specialties with marked stress. Furthermore, negative association was recorded with increasing duration of working hours (R<sup>2</sup> =0.90, p<0.</strong><strong>05). </strong><strong><em>Conclusion:</em></strong><strong> Tension-type headache is the most widespread type of headache followed by migraine. There was a negative association between the number of years of work, and disability score. On the contrary, there was a positive association between work shifts and specialties exposed to marked stress such as surgeons, ICU physicians and emergency doctors with increasing disability score. Notably, </strong><strong>the disability score increases exponentially with the increasing days of headache.</strong>
<strong><em> </em></strong>https://scumj.journals.ekb.eg/article_43590_b4e6ef05e89f55e039e9afcd432894dc.pdfSuez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Early Outcome Following Modified Blalock-Taussig Shunt in Cyanotic Congenital Heart Diseases: Determinants of Morbidity and Mortality1771894362610.21608/scumj.2017.43626ENShady AbdelmoneimDepartment of Cardiothoracic Surgery, Faculty of Medicine, Suez Canal University, EgyptHany FaisalDepartment of Cardiothoracic Surgery, Faculty of Medicine, Suez Canal University, EgyptHassan HassanDepartment of Cardiothoracic Surgery, Faculty of Medicine, Suez Canal University, EgyptHany El-DomiatyDepartment of Cardiothoracic Surgery, Faculty of Medicine, Suez Canal University, EgyptJournal Article20190803<strong><em>Background: Modified Blalock-Taussig Shunt</em></strong><strong> is the most commonly used palliative shunt procedure in congenital heart disorders and is associated with significant morbidity and mortality. <em>Aim:</em> to </strong><strong>improve the outcome following this surgical intervention. <em>Subjects and Methods:</em> Data about all children undergoing <em>Modified Blalock-Taussig Shunt</em> in Suez Canal University Hospitals and Cairo University Specialized Children Hospital in the time interval between March 2014 and February 2015 has been collected in three phases; pre- intra- and post-operatively then analyzed statistically. <em>Results:</em> Mortality in our study was 50%. The main risk factors for mortality in our study were weight urgency pre-operative prostene infusion cardiopulmonary bypass graft size and wound infection. Regarding shunt occlusion weight shunt size and intra-operative administration of protamine were statistically significant risk factors. <em>Conclusion:</em> Mortality rates decreased significantly with increasing weight. Cardiopulmonary Bypass graft size and wound infection were noted to be definite risk factors for mortality. Regarding acute shunt occlusion risk factors of statistical importance were weight intra-operative protamine and graft size. </strong>
<strong><em> </em></strong>https://scumj.journals.ekb.eg/article_43626_7adb8412112ef1721e6f901798d944ef.pdfSuez Canal University, Faculty of MedicineSuez Canal University Medical Journal1110-699920220171001Effect of Stem Cells versus Statins on the Mucous Membrane and Salivary Glands of the Tongue of Induced- Diabetic Rats19020013641910.21608/scumj.2017.136419ENMai FakhrDepartment of Oral Biology, Faculty of Dentistry, Sinai university, EgyptEnas HegazyDepartment of Oral Biology, Faculty of Dentistry, Suez Canal University, EgyptLaila S.GhaliDepartment of Oral Biology, Faculty of Oral and Dental Medicine, Cairo University, Egypt.Journal Article20210106<strong><em>Background:</em></strong><strong> Diabetes Mellitus (DM) is one of the most prevalent metabolic diseases. Statins are the most commonly prescribed medications to lower plasma LDL-C levels. Statins also have been shown to reduce the progression of atherosclerotic plaques.</strong><strong>Stem cell (SC) therapy is emerging as a potentially revolutionary way to treat disease and injury with wide ranging medical benefits.</strong><strong><em>Aim:</em></strong><strong> to evaluate the effect of SC versus simvastatin on the mucous membrane and salivary glands of the tongue of rats with streptozotocin-induced DM. <em>Material and Methods: </em>Seventy-five male albino rats (weight 150-180gr) were divided into the following groups: Group1.1 (15 rats) served as controls.</strong><strong>Group 2.1 (15 rats) were subjected to a single intraperitoneal injection of streptozotocin (60mg/kg body weight) for induction of DM. Group 3.1 (15 rats) were subjected to induction of DM (as in group 2.1). One week later, the animals were treated with simvastatin in a daily intraperitoneal dose of 5mg/kg body weight. Group 4 (30 rats) were subdivided into:</strong><strong>Subgroup.4.1 (15 rats) subjected to induction of DM (as in group 2.1). One week later they were subjected to single intravenous infusion of mesenchymal bone marrow SCs. Subgroup. 4.2 (15 rats)</strong><strong>were used for isolation and culture of bone marrow SC.</strong><strong>By the end of the experimental periods all animals were sacrificed, and the tongue of all rats were dissected and processed for light and scanning electron microscopic examinations. <em>Results: </em>Examination of diabetic rats' tongues revealed atrophic and degenerative changes on the tongue papillae. </strong><strong>The examined tongues of the rats treated with simvastatin showed partial improvement in the histological picture while the</strong><strong> tongue of rats treated with SC showed almost normal histology. <em>Conclusion</em>: The anti-inflammatory effect of SMV on the diabetic tongue. Bone marrow-derived SC are responsible for repairing the tissues and replacing them when injured or exposed to tear, wear or diseases.</strong><br /> https://scumj.journals.ekb.eg/article_136419_3fae9d3634789ff966471c2f66113b17.pdf